Oscanoa T J, Cieza E C, Lizaraso-Soto F A, Guevara M L, Fujita R M, Parodi J F, Runzer-Colmenares F M, Romero-Ortuno R
Universidad de San Martín de Porres, Facultad de Medicina Humana, Instituto de Investigación, Alameda del Corregidor 1531, La Molina 15024 Lima, Perú, e-mail:
Geriatric Department, Hospital Almenara, ESSALUD, Av. Grau 800, La Victoria, Lima-13, Lima, Perú.
Adv Gerontol. 2020;33(4):686-690.
Aging can be associated with decreasing muscle strength, and related factors are comorbidities, sex, physical activity, and possibly genetic factors. Among genetic factors the renin-angiotensin system is of interest, but data on the Peruvian population is lacking. The objective of our study was to evaluate the association of grip strength and angiotensin convertase enzyme (ACE) polymorphism in Peruvian older people. A cross-sectional study in a convenience sample of 104 participants over 60 years in Lima, Perú, with analysis of the ACE polymorphism, was performed. We studied 104 participants, 46 men (44,2%) and 58 women (55,8%), with a mean age and standard deviation (SD) of 73,7 (7,4) years, range between 60-90 years. The frequency of D/D, I/D and I/I genotypes was 12,7; 43,7 and 43,7% respectively. The genotype distribution of ACE polymorphism agreed with the Hardy-Weinberg equilibrium (p=0,746). The mean (SD) of grip strength in the D/D, I/D and I/I polymorphisms were 24,8 (7,2); 22,8 (7,2) and 23,4 (7,6) kg respectively; no significant difference was observed (p=0,41) between genetic groups. In this small convenience sample of older Peruvians, no association was found between grip strength and ACE genotype.
衰老可能与肌肉力量下降有关，相关因素包括合并症、性别、身体活动以及可能的遗传因素。在遗传因素中，肾素 - 血管紧张素系统备受关注，但秘鲁人群的数据尚缺。我们研究的目的是评估秘鲁老年人握力与血管紧张素转换酶（ACE）多态性之间的关联。在秘鲁利马对104名60岁以上参与者的便利样本进行了横断面研究，并对ACE多态性进行了分析。我们研究了104名参与者，其中46名男性（44.2%）和58名女性（55.8%），平均年龄和标准差（SD）为73.7（7.4）岁，年龄范围在60 - 90岁之间。D/D、I/D和I/I基因型的频率分别为12.7%、43.7%和43.7%。ACE多态性的基因型分布符合哈迪 - 温伯格平衡（p = 0.746）。D/D、I/D和I/I多态性中握力的平均值（SD）分别为24.8（7.2）、22.8（7.2）和23.4（7.6）千克；各基因组之间未观察到显著差异（p = 0.41）。在这个秘鲁老年人群的小型便利样本中，未发现握力与ACE基因型之间存在关联。
