[角膜缘干细胞移植的研究进展]
[Research progress on limbal stem cell transplantation].
作者信息
Wang L Y, Liang Q F
机构信息
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China.
出版信息
Zhonghua Yan Ke Za Zhi. 2020 Dec 11;56(12):956-960. doi: 10.3760/cma.j.cn112142-20201022-00526.
Limbal Stem Cell Deficiency (LSCD) is an ocular surface disease caused by the decrease of the quantity and dysfunction of limbal stem cell, which is characterized by conjunctivalization and other signs of epithelial dysfunction. For sever LSCD, surgery is the main treatment way. Recently, plenty of researches published the outcomes of different operation methods. This article summarized five major operations, including conjunctival limbal autograft (CLAU), simple limbal epithelial transplantation (SLET), limbal allograft, cultivated limbal stem cell transplantation (CLET) and cultivated oral mucosal epithelial transplantation (COMET). .
角膜缘干细胞缺乏症（LSCD）是一种由角膜缘干细胞数量减少和功能障碍引起的眼表疾病，其特征为结膜化和上皮功能障碍的其他体征。对于严重的LSCD，手术是主要的治疗方式。最近，大量研究发表了不同手术方法的结果。本文总结了五种主要手术，包括结膜角膜缘自体移植（CLAU）、单纯角膜缘上皮移植（SLET）、角膜缘同种异体移植、培养的角膜缘干细胞移植（CLET）和培养的口腔黏膜上皮移植（COMET）。
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