Department of Pathology, Maulana Azad Medical College, New Delhi, India.
Department of Surgery, Maulana Azad Medical College, New Delhi, India.
J Cancer Res Ther. 2020 Oct-Dec;16(6):1408-1411. doi: 10.4103/jcrt.JCRT_300_18.
Phyllodes tumor is a group of biphasic fibroepithelial tumors of the breast, graded as benign, borderline, and malignant. The grading of breast phyllodes remains a challenging task for the pathologists as the prognosis, and further treatment depends on it. In this study, an effort has been made to grade phyllodes tumor on the basis of immunohistochemistry.
Vascular endothelial growth factor, CD10, and factor 8 have been used as immunohistochemical markers for grading.
We have found a significant correlation between the expression of these markers and grading of phyllodes tumor. Positive correlation was also found amongst expression of all three markers. To conclude, increased expression of these markers with increasing grade can aid in diagnosis and guide treatment.
叶状肿瘤是一种乳腺的双相上皮-间叶性肿瘤，分为良性、交界性和恶性。乳腺叶状肿瘤的分级对病理学家来说仍然是一项具有挑战性的任务，因为预后和进一步的治疗取决于分级。在这项研究中，我们试图基于免疫组织化学来对叶状肿瘤进行分级。
血管内皮生长因子、CD10 和因子 8 已被用作分级的免疫组织化学标志物。
我们发现这些标志物的表达与叶状肿瘤的分级之间存在显著相关性。还发现这三种标志物的表达之间存在正相关。总之，随着分级的增加，这些标志物的表达增加可以辅助诊断并指导治疗。
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