Hachisuka Yasuki, Fujioka Shinji, Uomoto Masashi, Johira Hiroki
Dept. of Thoracic Surgery, Matsuyama Shimin Hospital.
Gan To Kagaku Ryoho. 2020 Dec;47(12):1711-1714.
A 70-year-old man who was diagnosed with a cStage ⅣA lung adenocarcinoma was in a stable condition for a long time after the first chemotherapy with gefitinib. However, 2 years 4 months later, the lung cancer progressed, and he was diagnosed with Stage Ⅲ gastric cancer. Since the administration of afatinib as the second-line chemotherapy was ineffective, nivolumab was administered as the third-line chemotherapy. The lung cancer showed a partial response to nivolumab treatment, but the gastric cancer remained unresponsive. We report a rare case of immune checkpoint inhibitor administration for synchronous double primary cancers.
一名70岁男性被诊断为cStage ⅣA期肺腺癌，在首次使用吉非替尼化疗后长期处于稳定状态。然而，2年4个月后，肺癌进展，他又被诊断出患有Ⅲ期胃癌。由于二线化疗使用阿法替尼无效，于是使用纳武单抗作为三线化疗药物。肺癌对纳武单抗治疗显示出部分缓解，但胃癌仍无反应。我们报告了一例罕见的同步双原发性癌症使用免疫检查点抑制剂治疗的病例。
