难治性精神分裂症的神经生物学：抗精神病药物耐药的途径及未来研究路线图。
The Neurobiology of Treatment-Resistant Schizophrenia: Paths to Antipsychotic Resistance and A Roadmap for Future Research.
作者信息
Potkin Steven G, Kane John M, Correll Christoph U, Lindenmayer Jean-Pierre, Agid Ofer, Marder Stephen R, Olfson Mark, Howes Oliver D
出版信息
Focus (Am Psychiatr Publ). 2020 Oct;18(4):456-465. doi: 10.1176/appi.focus.18309. Epub 2020 Nov 5.
Abstract
(Reprinted with permission from (2020) 6:1).
摘要
（经许可重印自（2020年）第6卷第1期）
相似文献
1
The Neurobiology of Treatment-Resistant Schizophrenia: Paths to Antipsychotic Resistance and A Roadmap for Future Research.难治性精神分裂症的神经生物学：抗精神病药物耐药的途径及未来研究路线图。
Focus (Am Psychiatr Publ). 2020 Oct;18(4):456-465. doi: 10.1176/appi.focus.18309. Epub 2020 Nov 5.
2
Subtyping Schizophrenia by Treatment Response: Antipsychotic Development and the Central Role of Positive Symptoms.根据治疗反应对精神分裂症进行亚型分类：抗精神病药物研发及阳性症状的核心作用。
Focus (Am Psychiatr Publ). 2016 Jul;14(3):396-402. doi: 10.1176/appi.focus.140306. Epub 2016 Jul 8.
3
Antipsychotic Polypharmacy and Metabolic Syndrome in Schizophrenia: A Review of Systematic Reviews.精神分裂症中的抗精神病药物联合使用与代谢综合征：系统评价综述
Focus (Am Psychiatr Publ). 2020 Oct;18(4):482-492. doi: 10.1176/appi.focus.18307. Epub 2020 Nov 5.
4
Does cannabidiol have a role in the treatment of schizophrenia?大麻二酚在精神分裂症的治疗中是否起作用？
Schizophr Res. 2016 Oct;176(2-3):281-290. doi: 10.1016/j.schres.2016.06.022. Epub 2016 Jul 1.
5
Presynaptic Dopamine Capacity in Patients with Treatment-Resistant Schizophrenia Taking Clozapine: An [F]DOPA PET Study.服用氯氮平的难治性精神分裂症患者的突触前多巴胺功能：一项[F]多巴PET研究。
Neuropsychopharmacology. 2017 Mar;42(4):941-950. doi: 10.1038/npp.2016.258. Epub 2016 Nov 18.
6
Hypofunctional Dopamine Uptake and Antipsychotic Treatment-Resistant Schizophrenia.多巴胺摄取功能减退与抗精神病药物治疗抵抗性精神分裂症
Front Psychiatry. 2019 May 28;10:314. doi: 10.3389/fpsyt.2019.00314. eCollection 2019.
7
Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia.抗精神病药物与神经可塑性：对精神分裂症治疗及神经生物学的见解
Biol Psychiatry. 2001 Nov 15;50(10):729-42. doi: 10.1016/s0006-3223(01)01267-7.
8
Analysis of treatment-resistant schizophrenia and 384 markers from candidate genes.治疗抵抗性精神分裂症及候选基因 384 个标记物的分析。
Pharmacogenet Genomics. 2012 Nov;22(11):807-11. doi: 10.1097/FPC.0b013e3283586c04.
9
Does cognitive impairment in treatment-resistant and ultra-treatment-resistant schizophrenia differ from that in treatment responders?治疗抵抗和超治疗抵抗精神分裂症的认知障碍是否与治疗反应者不同？
Psychiatry Res. 2015 Dec 30;230(3):811-8. doi: 10.1016/j.psychres.2015.10.036. Epub 2015 Oct 31.
10
Electroconvulsive Therapy Augmentation in Clozapine-Resistant Schizophrenia: A Prospective, Randomized Study.电休克治疗增强氯氮平难治性精神分裂症疗效的前瞻性随机研究
Focus (Am Psychiatr Publ). 2019 Jan;17(1):76-82. doi: 10.1176/appi.focus.17106. Epub 2019 Jan 7.
引用本文的文献
1
Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis.难治性精神分裂症的独特结构缺陷及其假定的神经递质基础：基于源的形态学分析
Neuropsychopharmacology. 2025 May 28. doi: 10.1038/s41386-025-02135-x.
2
Response to clozapine in treatment resistant schizophrenia is related to alterations in regional cerebral blood flow.氯氮平治疗难治性精神分裂症的疗效与局部脑血流量的改变有关。
Schizophrenia (Heidelb). 2024 Dec 23;10(1):122. doi: 10.1038/s41537-024-00544-3.
3
Real-World Treatment of Schizophrenia in Adults With a 22q11.2 Microdeletion: Traitement dans le monde réel de la schizophrénie chez des adultes atteints du syndrome de microdélétion 22q11.2.22q11.2微缺失成年精神分裂症患者的真实世界治疗：22q11.2微缺失综合征成年患者精神分裂症的真实世界治疗
Can J Psychiatry. 2025 Mar;70(3):160-170. doi: 10.1177/07067437241293983. Epub 2024 Dec 6.
4
Knowledge domain and trends in treatment-resistant schizophrenia (TRS) research based on CiteSpace bibliometrics analysis.基于CiteSpace文献计量学分析的难治性精神分裂症（TRS）研究的知识领域与趋势
Front Pharmacol. 2024 Nov 5;15:1478625. doi: 10.3389/fphar.2024.1478625. eCollection 2024.
5
Antipsychotic prescription patterns among schizophrenia patients in Guangdong Province, China's 686 program: A retrospective study.中国“686 项目”中广东省精神分裂症患者的抗精神病药物处方模式：一项回顾性研究。
Medicine (Baltimore). 2024 Sep 13;103(37):e39629. doi: 10.1097/MD.0000000000039629.
6
Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia.精神分裂症结构协变网络与抗精神病药物治疗反应的相关性研究。
Schizophr Bull. 2024 Mar 7;50(2):382-392. doi: 10.1093/schbul/sbad160.
7
Greater Choline-Containing Compounds and Myo-inositol in Treatment-Resistant Versus Responsive Schizophrenia: A H-Magnetic Resonance Spectroscopy Meta-analysis.治疗抵抗与治疗反应性精神分裂症患者中胆碱含量较高的化合物和肌醇：一项 H 磁共振波谱学荟萃分析。
Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Feb;9(2):137-145. doi: 10.1016/j.bpsc.2023.10.008. Epub 2023 Nov 2.
8
Altered Patterns of Brain Glucose Metabolism Involve More Extensive and Discrete Cortical Areas in Treatment-resistant Schizophrenia Patients Compared to Responder Patients and Controls: Results From a Head-to-Head 2-[18F]-FDG-PET Study.与应答者患者和对照相比，治疗抵抗性精神分裂症患者大脑葡萄糖代谢模式改变涉及更广泛和更离散的皮质区域：一项头对头 2-[18F]-FDG-PET 研究的结果。
Schizophr Bull. 2023 Mar 15;49(2):474-485. doi: 10.1093/schbul/sbac147.
9
Reduced cortical cerebral blood flow in antipsychotic-free first-episode psychosis and relationship to treatment response.抗精神病药治疗首发精神分裂症患者皮质脑血流减少与治疗反应的关系。
Psychol Med. 2023 Aug;53(11):5235-5245. doi: 10.1017/S0033291722002288. Epub 2022 Aug 25.
10
Systematic Review of Functional MRI Applications for Psychiatric Disease Subtyping.精神疾病亚型功能磁共振成像应用的系统评价
Front Psychiatry. 2021 Oct 22;12:665536. doi: 10.3389/fpsyt.2021.665536. eCollection 2021.
Zotero 插件