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俯卧位通气联合股-股静脉体外膜肺氧合用于新型冠状病毒肺炎治疗

Prone position ventilation and femoro-femoral veno-venous extracorporeal membrane oxygenation for COVID-19 treatment.

作者信息

Maeda Akiko, Nabeya Daijiro, Nagano Hiroaki, Yagi Nobuhito, Miyagi Tadayoshi, Kishaba Tomoo

机构信息

Department of Respiratory Internal Medicine Okinawa Chubu Hospital Okinawa Japan.

Department of Cardiovascular Medicine Okinawa Chubu Hospital Okinawa Japan.

出版信息

Respirol Case Rep. 2020 Dec 15;9(1):e00700. doi: 10.1002/rcr2.700. eCollection 2021 Jan.

DOI:10.1002/rcr2.700
PMID:33343904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7737602/
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has resulted in significant morbidity and mortality worldwide. Approximately 5% of COVID-19 patients who suffer from pneumonia develop critical respiratory failure. Here, we report the case of a healthy 52-year-old man who had respiratory failure owing to SARS-CoV-2 infection and was treated using femoro-femoral veno-venous extracorporeal membrane oxygenation (VV-ECMO) and prone position ventilation (PPV). After this treatment, his blood oxygen levels, chest high-resolution computed tomography findings, and clinical parameters significantly improved. He was decannulated from VV-ECMO on day 6 and finally extubated on day 11. To our knowledge, this is the first reported case of SARS-CoV-2-associated acute respiratory distress syndrome that was successfully treated with a combination of femoro-femoral VV-ECMO and PPV.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引发了2019冠状病毒病(COVID-19),在全球范围内导致了大量发病和死亡。约5%的COVID-19肺炎患者会发展为严重呼吸衰竭。在此,我们报告一例52岁健康男性病例,该患者因感染SARS-CoV-2而出现呼吸衰竭,接受了股-股静脉-静脉体外膜肺氧合(VV-ECMO)和俯卧位通气(PPV)治疗。经过此治疗后,他的血氧水平、胸部高分辨率计算机断层扫描结果及临床参数均显著改善。他在第6天撤掉了VV-ECMO插管,并最终在第11天拔管。据我们所知,这是首例报告的通过股-股VV-ECMO和PPV联合成功治疗的SARS-CoV-2相关急性呼吸窘迫综合征病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047c/7737602/3a666b7aa729/RCR2-9-e00700-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047c/7737602/3bb12d65f8df/RCR2-9-e00700-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047c/7737602/3a666b7aa729/RCR2-9-e00700-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047c/7737602/3bb12d65f8df/RCR2-9-e00700-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/047c/7737602/3a666b7aa729/RCR2-9-e00700-g002.jpg

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引用本文的文献

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Crit Care. 2021 Mar 19;25(1):111. doi: 10.1186/s13054-021-03537-1.

本文引用的文献

1
Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China.中国武汉 2019 年冠状病毒病肺炎患者急性呼吸窘迫综合征和死亡的相关危险因素。
JAMA Intern Med. 2020 Jul 1;180(7):934-943. doi: 10.1001/jamainternmed.2020.0994.
2
Preparing for the Most Critically Ill Patients With COVID-19: The Potential Role of Extracorporeal Membrane Oxygenation.为新冠肺炎重症患者做准备:体外膜肺氧合的潜在作用
JAMA. 2020 Apr 7;323(13):1245-1246. doi: 10.1001/jama.2020.2342.
3
Prone positioning in severe acute respiratory distress syndrome.
俯卧位通气治疗严重急性呼吸窘迫综合征。
N Engl J Med. 2013 Jun 6;368(23):2159-68. doi: 10.1056/NEJMoa1214103. Epub 2013 May 20.