Gürbüz Ali Sami, Göde Funda, Kılıç Fatma, Gürbüz Zeynep Umay, Deveer Rüya
Novafertil IVF Center, Clinict of Obstetrics and Gynecology, Konya Turkey.
Bahçeşehir University Faculty of Medicine, Department of Obstetrics and Gynecology, İstanbul, Turkey.
Turk J Obstet Gynecol. 2020 Dec;17(4):314-317. doi: 10.4274/tjod.galenos.2020.65031. Epub 2020 Dec 10.
Ovarian Hyperstimulation syndrome (OHSS) is a rare condition in patients with hypogonadotropic hypogonadism. Two patients with hypogonadotropic hypogonadism are reported, a rare case of severe OHSS and a case of prevented OHSS via gonadotropin-releasing hormone (GnRH) agonist trigger, respectively. The first case was a 31-year-old patient. In vitro fertilization (IVF) treatment was performed three times but the patient never developed OHSS. The first patient was diagnosed as having severe OHSS on the ninth day after the fresh embryo transfer. She stayed 66 days in hospital and 50.5 litres of fluid were aspirated from her abdomen. The second case was a 26-year-old and primary infertile patient. She had never undergone IVF treatment. The GnRH agonist stimulation test was performed before IVF treatment. After the ovarian stimulation, GnRH agonist trigger was given. Thirty-two oocytes were retrieved from the ovaries and OHSS did not occur. Although severe OHSS is rare, it can develop in patients hypogonadotropic hypogonadism. If a GnRH stimulation test is performed before ovarian stimulation, OHSS can be prevented because the test allows agonist triggering instead of hCG in hypogonadotropic hypogonadism.
卵巢过度刺激综合征（OHSS）在低促性腺激素性性腺功能减退患者中是一种罕见病症。本文报告了两名低促性腺激素性性腺功能减退患者，分别为一例罕见的严重OHSS病例和一例通过促性腺激素释放激素（GnRH）激动剂扳机成功预防OHSS的病例。首例患者为一名31岁女性。其接受了三次体外受精（IVF）治疗，但从未发生过OHSS。该患者在新鲜胚胎移植后第9天被诊断为严重OHSS。她住院66天，从腹部抽出了50.5升液体。第二例患者为一名26岁的原发性不孕女性。她从未接受过IVF治疗。在IVF治疗前进行了GnRH激动剂刺激试验。卵巢刺激后，给予GnRH激动剂扳机。从卵巢中获取了32枚卵母细胞，未发生OHSS。虽然严重OHSS较为罕见，但可在低促性腺激素性性腺功能减退患者中发生。如果在卵巢刺激前进行GnRH刺激试验，OHSS可得到预防，因为该试验允许在低促性腺激素性性腺功能减退中使用激动剂扳机而非人绒毛膜促性腺激素（hCG）。
