Samal Swagatika, Sable Mukund
All India Institute of Medical Sciences, Department of Pathology. Bhubaneswar, Orissa, India.
Autops Case Rep. 2020 May 6;10(2):e2020167. doi: 10.4322/acr.2020.167.
Long term use of D-penicillamine for Wilson's disease can be associated with many adverse reactions and systemic side effects. We report the case of a 28-year-old male patient diagnosed with Wilson's disease presenting with a serpiginous raised violaceous skin lesion in the anterior aspect of the neck over the last six months and two small papules with central umbilication during the last month. Histopathological examination of skin lesions demonstrated transepidermal perforating channel, and the Verhoeff's-van Gieson stain showed marked increase number of irregular serrated elastic fibers suggesting the diagnosis of D- penicillamine induced elastosis perforans serpiginosa.
长期使用D-青霉胺治疗威尔逊病可能会引发多种不良反应和全身性副作用。我们报告了一例28岁男性患者，该患者被诊断为威尔逊病，在过去六个月中颈部前方出现了一个匐行性隆起的紫罗兰色皮肤病变，在上个月出现了两个中央有脐凹的小丘疹。皮肤病变的组织病理学检查显示有经表皮穿通性通道，Verhoeff-Van Gieson染色显示不规则锯齿状弹性纤维数量明显增加，提示诊断为D-青霉胺诱发的匐行性穿通性弹力纤维病。
