Wenzel Mike, Deuker Marina, Welte Maria N, Hoeh Benedikt, Preisser Felix, Homrich Till, Kempf Volkhard A J, Hogardt Michael, Mandel Philipp, Karakiewicz Pierre I, Chun Felix K H, Kluth Luis A
Department of Urology, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.
Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada.
Front Surg. 2020 Dec 3;7:609661. doi: 10.3389/fsurg.2020.609661. eCollection 2020.
This study aims to evaluate catheter management in acute epididymitis (AE) patients requiring inpatient treatment and risk factors predicting severity of disease. Patients with diagnosed AE and inpatient treatment between 2004 and 2019 at the University Hospital Frankfurt were analyzed. A risk score, rating severity of AE, including residual urine > 100 ml, fever > 38.0°C, C-reactive protein (CRP) > 5 mg/dl, and white blood count (WBC) > 10/nl was introduced. Of 334 patients, 107 (32%) received a catheter (transurethral (TC): = 53, 16%, suprapubic (SPC): = 54, 16%). Catheter patients were older, exhibited more comorbidities, and had higher CRP and WBC compared with the non-catheter group (NC). Median length of stay (LOS) was longer in the catheter group (7 vs. 6 days, < 0.001), whereas necessity of abscess surgery and recurrent epididymitis did not differ. No differences in those parameters were recorded between TC and SPC. According to our established risk score, 147 (44%) patients exhibited 0-1 () and 187 (56%) 2-4 risk factors (). In the high-risk group, patients received a catheter significantly more often than with low-risk (TC: 22 vs. 9%; SPC: 19 vs. 12%, both ≤ 0.01). Catheter or high-risk patients exhibited positive urine cultures more frequently than NC or low-risk patients. LOS was comparable between high-risk patients with catheter and low-risk NC patients. Patients with AE who received a catheter at admission were older, multimorbid, and exhibited more severe symptoms of disease compared with the NC patients. A protective effect of catheters might be attributable to patients with adverse risk constellations or high burden of comorbidities. The introduced risk score indicates a possibility for risk stratification.
本研究旨在评估需要住院治疗的急性附睾炎(AE)患者的导管管理情况以及预测疾病严重程度的危险因素。对2004年至2019年期间在法兰克福大学医院确诊为AE并接受住院治疗的患者进行了分析。引入了一个评估AE严重程度的风险评分,包括残余尿量>100 ml、发热>38.0°C、C反应蛋白(CRP)>5 mg/dl以及白细胞计数(WBC)>10/μl。在334例患者中,107例(32%)接受了导管插入术(经尿道(TC):n = 53,16%;耻骨上(SPC):n = 54,16%)。与非导管组(NC)相比,接受导管插入术的患者年龄更大,合并症更多,CRP和WBC更高。导管组的中位住院时间(LOS)更长(7天对6天,P<0.001),而脓肿手术的必要性和复发性附睾炎并无差异。TC和SPC之间在这些参数上未记录到差异。根据我们建立的风险评分,147例(44%)患者有0 - 1个(低风险)风险因素,187例(56%)有2 - 4个(高风险)风险因素。在高风险组中,患者接受导管插入术的频率显著高于低风险组(TC:22%对9%;SPC:19%对12%,均P≤0.01)。接受导管插入术的患者或高风险患者尿培养阳性的频率高于NC患者或低风险患者。高风险的导管插入术患者与低风险的NC患者的LOS相当。与NC患者相比,入院时接受导管插入术的AE患者年龄更大,合并多种疾病,且疾病症状更严重。导管的保护作用可能归因于具有不良风险组合或高合并症负担的患者。引入的风险评分表明了进行风险分层的可能性。