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心血管人体测量学:撒哈拉以南非洲地区大规模人群筛查最适合采用什么方法?

Cardiovascular Anthropometry: What Is Best Suited for Large-Scale Population Screening in Sub-Saharan Africa?

作者信息

Agbo Hadiza A, Zoakah Ayuba I, Isichei Christian O, Sagay Atiene S, Achenbach Chad J, Okeahialam Basil N

机构信息

Department of Community Medicine, Jos University Teaching Hospital, Jos, Nigeria.

Department of Chemical Pathology, Jos University Teaching Hospital, Jos, Nigeria.

出版信息

Front Cardiovasc Med. 2020 Dec 3;7:522123. doi: 10.3389/fcvm.2020.522123. eCollection 2020.

Abstract

Body mass index (BMI) measures overweight/obesity. It, however, especially in sub-Saharan Africa (SSA), misclassifies cardiometabolic risk. Central obesity measures are superior. We therefore sought to compare BMI, waist-to-hip ratio (WHR) and abdominal height (AH) in predicting cardiovascular disease risk in sub-Saharan Africa. Subjects had blood pressures, BMI, and WHR determined. Blood pressure was taken, weight and height measured to generate BMI, and AH measured with a new locally fabricated abdominometer. The ability of the anthropometric indices in identifying abnormal individuals needing intervention was assessed with sensitivity, specificity, and area under the receiver operator characteristic curve. Adults totaling 1,508 (728 M/780 F) adults were studied. For BMI, 985 (65.3%) were normal, while 375 (24.9%), consisting of 233 males and 142 females, had normal WHR. Blood pressure was normal in 525 (34.8%) and 317 (21.0%) for systolic and diastolic blood pressures, respectively. Using BMI as gold standard, sensitivity, specificity, positive, and negative predictive values for WHR in males were 80.7, 37.5, 62.5, and 19.3%, respectively. For females and in the same order, they were 62.0, 34.3, 65.7, and 38.0%. For AH, it was equal in both genders at 82.6, 39.2, 60.8, and 17.4%. By receiver operating curves comparing AH, WHR, and BMI against blood pressure detection, the area under the curve was 0.745, 0.604, and 0.554 for AH, BMI, and WHR, respectively. Abdominometer-derived AH has a better sensitivity and greater area under the receiver operator curve compared with BMI and WHR in this sub-Sahara African population; implying superiority as a cardiovascular anthropometric index.

摘要

体重指数(BMI)用于衡量超重/肥胖情况。然而,尤其是在撒哈拉以南非洲地区(SSA),它会对心脏代谢风险进行错误分类。中心性肥胖指标更具优势。因此,我们试图比较BMI、腰臀比(WHR)和腹高(AH)在预测撒哈拉以南非洲地区心血管疾病风险方面的作用。研究对象测定了血压、BMI和WHR。测量血压、体重和身高以计算BMI,并用一种新的当地制造的腹围计测量AH。通过敏感性、特异性和受试者工作特征曲线下面积评估人体测量指标识别需要干预的异常个体的能力。共研究了1508名成年人(728名男性/780名女性)。对于BMI,985人(65.3%)正常,而375人(24.9%),包括233名男性和142名女性,WHR正常。收缩压和舒张压正常的人数分别为525人(34.8%)和317人(21.0%)。以BMI作为金标准,男性WHR的敏感性、特异性、阳性预测值和阴性预测值分别为80.7%、37.5%、62.5%和19.3%。女性的相应数值分别为62.0%、34.3%、65.7%和38.0%。对于AH,男女两性的相应数值均为82.6%、39.2%、60.8%和17.4%。通过比较AH、WHR和BMI与血压检测的受试者工作曲线,AH、BMI和WHR的曲线下面积分别为0.745、0.604和0.554。在这个撒哈拉以南非洲人群中,与BMI和WHR相比,腹围计得出的AH具有更好的敏感性和更大的受试者工作曲线下面积;这意味着其作为心血管人体测量指标具有优越性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b7f/7744454/5921448c249d/fcvm-07-522123-g0001.jpg

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