Huang Su-Jing, Wang Hong-Wei, Wu Hai-Fang, Wei Qiu-Yuan, Luo Shu, Xu Lin, Guan Hong-Qiong
Department of Obstetrics, The Second Affiliated Hospital of Hainan Medical College, Haikou 570311, Hainan Province, China.
World J Clin Cases. 2020 Nov 26;8(22):5529-5534. doi: 10.12998/wjcc.v8.i22.5529.
Gestational diabetes mellitus (GDM) raises the risk of high blood pressure and may cause a series of life-threatening complications in pregnant women. Screening and management of GDM and gestational hypertension (GH) in pregnancy helps to control and reduce these risks and prevent adverse effects on mothers and their fetuses. Currently, the majority criteria used for screening of diabetes mellitus is oral glucose tolerance tests, and blood pressure test is usually used for the screening and diagnosis of hypertension. However, these criteria might not anticipate or detect all GDM or GH cases. Therefore, new specific predictive and diagnostic tools should be evaluated for this population. This study selected three biomarkers of osteoprotegerin (OPG), interleukin (IL) and hepatocyte growth factor (HGF) for GDM and GH predication and diagnosis.
To explore the feasibility of changes in placental and serum OPG, IL and HGF as tools for prediction and diagnosis of diabetes and hypertension in pregnant women.
From January 2018 to January 2019, 44 pregnant women with GDM and GH were selected as an observation group, and 44 healthy pregnant women were selected as a control group in the same period. Serum OPG, IL and HGF were compared between the two groups.
The levels of OPG and HGF in the observation group were lower than in the control group, and the level of IL-1β was higher in the observation group than in the control group (all < 0.05). Furthermore, OPG and HGF were negatively associated with gestational diabetes and gestational hypertension, while IL-1β was positively associated with GDM complicated with GH (all < 0.05).
The evaluation of serum OPG, HGF and IL-1β levels in patients with coexistent gestational diabetes complicated with hypertension can predict the degree of disease and play an important role in the follow-up treatment and prognosis prediction.
妊娠期糖尿病（GDM）会增加高血压风险，并可能在孕妇中引发一系列危及生命的并发症。孕期对GDM和妊娠高血压（GH）进行筛查和管理有助于控制和降低这些风险，并预防对母亲及其胎儿的不良影响。目前，用于糖尿病筛查的主要标准是口服葡萄糖耐量试验，而血压测试通常用于高血压的筛查和诊断。然而，这些标准可能无法预测或检测出所有GDM或GH病例。因此，应针对这一人群评估新的特异性预测和诊断工具。本研究选择骨保护素（OPG）、白细胞介素（IL）和肝细胞生长因子（HGF）这三种生物标志物用于GDM和GH的预测和诊断。
探讨胎盘和血清中OPG、IL和HGF的变化作为预测和诊断孕妇糖尿病和高血压工具的可行性。
选取2018年1月至2019年1月期间44例患有GDM和GH的孕妇作为观察组，同期选取44例健康孕妇作为对照组。比较两组血清OPG、IL和HGF水平。
观察组OPG和HGF水平低于对照组，观察组IL-1β水平高于对照组（均P<0.05）。此外，OPG和HGF与妊娠期糖尿病和妊娠高血压呈负相关，而IL-1β与合并GH的GDM呈正相关（均P<0.05）。
对合并妊娠期糖尿病和高血压患者的血清OPG、HGF和IL-1β水平进行评估，可预测疾病程度，对后续治疗及预后预测具有重要作用。
