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地黄和山茱萸防治糖尿病肾病的作用机制与 AGE-RAGE 信号通路有关。

Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway.

机构信息

Hanlin College, Nanjing University of Chinese Medicine, Taizhou 225300, China.

Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.

出版信息

J Diabetes Res. 2020 Dec 2;2020:8358102. doi: 10.1155/2020/8358102. eCollection 2020.

DOI:10.1155/2020/8358102
PMID:33344651
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7725584/
Abstract

BACKGROUND AND AIMS

Radix Rehmanniae and Corni Fructus (RC) have been widely applied to treat diabetic nephropathy (DN) for centuries. But the mechanism of how RC plays the therapeutic role against DN is unclear as yet.

METHODS

The information about RC was obtained from a public database. The active compounds of RC were screened by oral bioavailability (OB) and drug-likeness (DL). Gene ontology (GO) analysis was performed to realize the key targets of RC, and an active compound-potential target network was created. The therapeutic effects of RC active compounds and their key signal pathways were preliminarily probed via network pharmacology analysis and animal experiments.

RESULTS

In this study, 29 active compounds from RC and 64 key targets related to DN were collected using the network pharmacology method. The pathway enrichment analysis showed that RC regulated advanced glycosylation end product (AGE-) RAGE and IL-17 signaling pathways to treat DN. The animal experiments revealed that RC significantly improved metabolic parameters, inflammation renal structure, and function to protect the kidney against DN.

CONCLUSIONS

The results revealed the relationship between multicomponents and multitargets of RC. The administratiom of RC might remit the DM-induced renal damage through the AGE-RAGE signaling pathway to improve metabolic parameters and protect renal structure and function.

摘要

背景与目的

地黄和山茱萸（RC）已被广泛用于治疗糖尿病肾病（DN）数百年。但 RC 如何发挥治疗 DN 的作用机制尚不清楚。

方法

从公共数据库中获取 RC 的信息。通过口服生物利用度（OB）和药物相似性（DL）筛选 RC 的活性化合物。进行基因本体论（GO）分析以实现 RC 的关键靶点，并创建活性化合物-潜在靶点网络。通过网络药理学分析和动物实验初步探讨 RC 活性化合物及其关键信号通路的治疗效果。

结果

本研究采用网络药理学方法从 RC 中收集了 29 种活性化合物和 64 个与 DN 相关的关键靶点。通路富集分析表明，RC 通过调节晚期糖基化终产物（AGE）-RAGE 和 IL-17 信号通路来治疗 DN。动物实验表明，RC 可显著改善代谢参数、炎症性肾结构和功能，从而保护肾脏免受 DN 的损害。

结论

结果揭示了 RC 的多成分和多靶点之间的关系。RC 的给药可能通过 AGE-RAGE 信号通路减轻 DM 引起的肾脏损伤，从而改善代谢参数并保护肾脏结构和功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9c/7725584/bdc3d99c46af/JDR2020-8358102.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9c/7725584/17c68de2d14b/JDR2020-8358102.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9c/7725584/87dd4594f2ac/JDR2020-8358102.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9c/7725584/bdc3d99c46af/JDR2020-8358102.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9c/7725584/17c68de2d14b/JDR2020-8358102.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9c/7725584/e1049dae6a90/JDR2020-8358102.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9c/7725584/369708714780/JDR2020-8358102.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9c/7725584/d3c6a3848ac9/JDR2020-8358102.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9c/7725584/1269d6c17739/JDR2020-8358102.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9c/7725584/6afcdb0763cf/JDR2020-8358102.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9c/7725584/496545ea34da/JDR2020-8358102.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9c/7725584/87dd4594f2ac/JDR2020-8358102.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9c/7725584/bdc3d99c46af/JDR2020-8358102.009.jpg

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