Liao Kuang-Ming, Lin Cheng-Li, Shen Te-Chun
Department of Internal Medicine, Chi Mei Medical Center, Chiali, Tainan, Taiwan.
Management Office for Health Data, China Medical University Hospital , Taichung, Taiwan.
Open Med (Wars). 2020 Oct 8;15(1):1012-1018. doi: 10.1515/med-2020-0225. eCollection 2020.
Rheumatoid arthritis (RA) can lead to various pulmonary manifestations. Evidence shows the possible association between RA and pleural empyema.
We conducted a retrospective cohort study to investigate the risk of pleural empyema in patients with RA. The RA group ( = 29,061) included newly diagnosed adult patients between 2000 and 2012. The comparison group ( = 1,16,244) included individuals without RA at a 1:4 ratio of frequency matched by age, gender, and diagnosis year. The occurrence of pleural empyema was monitored until the end of 2013.
Patients with RA had a higher risk of developing pleural empyema than those without RA (23.6 vs 1.82 per 10,000 person-years, adjusted hazard ratio = 11.0, 95% confidence interval [CI] = 8.90-13.5). Furthermore, intensive care unit admission rates of pleural empyema were 37.7% in the RA group and 37.2% in the comparison group (adjusted odds ratio [OR] = 1.02, 95% CI = 0.66-1.57). The 30-day mortality rates of pleural empyema were 11.2% in the RA group and 10.9% in the comparison group (adjusted OR = 1.01, 95% CI = 0.51-1.88).
Patients with RA are at a greater risk of developing pleural empyema than those without RA.
类风湿关节炎（RA）可导致多种肺部表现。有证据表明RA与胸膜腔积脓之间可能存在关联。
我们进行了一项回顾性队列研究，以调查RA患者发生胸膜腔积脓的风险。RA组（n = 29,061）包括2000年至2012年间新诊断的成年患者。对照组（n = 116,244）包括年龄、性别和诊断年份频率匹配比例为1:4的无RA个体。对胸膜腔积脓的发生情况进行监测直至2013年底。
RA患者发生胸膜腔积脓的风险高于无RA患者（每10,000人年分别为23.6例和1.82例，调整后的风险比= 11.0，95%置信区间[CI]= 8.90 - 13.5）。此外，RA组胸膜腔积脓的重症监护病房入住率为37.7%，对照组为37.2%（调整后的优势比[OR]= 1.02，95% CI = 0.66 - 1.57）。RA组胸膜腔积脓的30天死亡率为11.2%，对照组为10.9%（调整后的OR = 1.01，95% CI = 0.51 - 1.88）。
RA患者发生胸膜腔积脓的风险高于无RA患者。
