达雷木单抗对流式细胞术的干扰导致浆细胞κ 轻链限制性假性表达。
Daratumumab Interference in Flow Cytometry Producing a False Kappa Light Chain Restriction in Plasma Cells.
机构信息
Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA.
出版信息
Lab Med. 2021 Jul 1;52(4):403-409. doi: 10.1093/labmed/lmaa107.
False kappa light chain restriction on hematogones (normal B-lineage precursors) has been described in patients on the therapeutic anti-CD38 monoclonal antibody daratumumab. In this article, we present a novel case report of pseudo-kappa light chain restriction on lambda-restricted neoplastic plasma cells in a patient with progressive plasma cell myeloma while on daratumumab. Flow cytometric technologists and pathologists need to be aware of this potential diagnostic pitfall.
在接受治疗性抗 CD38 单克隆抗体达妥木单抗治疗的患者中，已经描述了造血细胞（正常 B 细胞前体）的假 κ 轻链限制。本文报告了一例新的病例，在接受达妥木单抗治疗的进行性浆细胞骨髓瘤患者中，肿瘤性浆细胞呈 λ 限制的假 κ 轻链限制。流式细胞术技术人员和病理学家需要意识到这一潜在的诊断陷阱。
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