Royal Devon and Exeter Hospital, Exeter, UK.
Derriford Hospital, Plymouth, UK.
Int J Surg Pathol. 2021 Sep;29(6):648-652. doi: 10.1177/1066896920981632. Epub 2020 Dec 21.
Phyllodes tumors (PTs) represent a spectrum of rare, fibroepithelial neoplasms of the breast, which can be subcategorized as benign, borderline, or malignant based on their histological appearance. Accessory breast tissue may present anywhere along the embryological mammary ridge, and at distant locations as aberrant breast tissue. We present the case of a 56-year-old lady with an umbilical mass, thought to represent a strangulated hernia. Sections showed a fibroepithelial tumor with leaf-like ducts, conspicuous mitotic activity (up to 8 per 10 high-power fields), and focal infiltration into fat. Immunohistochemical studies showed diffuse positivity of epithelial cells for estrogen receptor, mammaglobin, GCDFP-15, and CK7. These findings were consistent with a borderline PT. This is the first case report of PT presenting as an umbilical mass, and the first extramammary borderline PT described.
叶状肿瘤（PTs）是一种罕见的乳腺纤维上皮性肿瘤，根据其组织学表现可分为良性、交界性或恶性。副乳腺组织可出现在沿胚胎乳腺嵴的任何部位，也可出现在异常乳腺组织的远处位置。我们报告了一例 56 岁女性脐部肿块，考虑为绞窄性疝。切片显示为叶状纤维上皮性肿瘤，有明显的导管样结构，有明显的有丝分裂活性（高达每 10 高倍视野 8 个），并伴有脂肪浸润。免疫组化研究显示上皮细胞弥漫性表达雌激素受体、乳球蛋白、GCDFP-15 和 CK7。这些发现与交界性 PT 一致。这是首例以脐部肿块为表现的 PT 病例报告，也是首例描述的乳腺外交界性 PT。
