Faculty of Pharmacy, DIT University, Dehradun, India.
Neurochem Int. 2021 Feb;143:104939. doi: 10.1016/j.neuint.2020.104939. Epub 2020 Dec 17.
Xanthones are important chemical class of bioactive products that confers therapeutic benefits. Of several xanthones, mangiferin is known to be distributed widely across several fruits, vegetables and medicinal plants. Mangiferin has been shown to exert neuroprotective effects in both in-vitro and in-vivo models. Mangiferin attenuates cerebral infarction, cerebral edema, lipid peroxidation (MDA), neuronal damage, etc. Mangiferin further potentiate levels of endogenous antioxidants to confer protection against the oxidative stress inside the neurons. Mangiferin is involved in the regulation of various signaling pathways that influences the production and levels of proinflammatory cytokines in brain. Mangiferin cosunteracted the neurotoxic effect of amyloid-beta, MPTP, rotenone, 6-OHDA etc and confer protection to neurons. These evidence suggested that the mangiferin may be a potential therapeutic strategy for the treatment of various neurological disorders. The present review demonstrated the pharmacodynamics-pharmacokinetics of mangiferin and neurotherapeutic potential in several neurological disorders with underlying mechanisms.
芒果苷是一类具有治疗作用的生物活性产物的重要化学类别。在几种芒果苷中，已知其广泛分布于几种水果、蔬菜和药用植物中。研究表明，芒果苷在体外和体内模型中均具有神经保护作用。芒果苷可减轻脑梗死、脑水肿、脂质过氧化（MDA）、神经元损伤等。芒果苷进一步增强内源性抗氧化剂的水平，以防止神经元内的氧化应激。芒果苷参与调节各种信号通路，影响大脑中促炎细胞因子的产生和水平。芒果苷对抗β淀粉样蛋白、MPTP、鱼藤酮、6-OHDA 等的神经毒性作用，并保护神经元。这些证据表明，芒果苷可能是治疗各种神经疾病的潜在治疗策略。本综述展示了芒果苷的药效学-药代动力学及其在几种神经疾病中的神经治疗潜力及其潜在机制。
