Department of Medical Physiology, College of Medicine, Texas A & M Health Science Center, Bryan Campus, Texas 77807, U.S.A.
Clin Sci (Lond). 2020 Dec 23;134(24):3237-3257. doi: 10.1042/CS20201023.
Hypertension is one of the most prevalent diseases that leads to end organ damage especially affecting the heart, kidney, brain, and eyes. Numerous studies have evaluated the association between hypertension and impaired sexual health, in both men and women. The detrimental effects of hypertension in men includes erectile dysfunction, decrease in semen volume, sperm count and motility, and abnormal sperm morphology. Similarly, hypertensive females exhibit decreased vaginal lubrication, reduced orgasm, and several complications in pregnancy leading to fetal and maternal morbidity and mortality. The adverse effect of hypertension on male and female fertility is attributed to hormonal imbalance and changes in the gonadal vasculature. However, mechanistic studies investigating the impact of hypertension on gonads in more detail on a molecular basis remain scarce. Hence, the aim of the current review is to address and summarize the effects of hypertension on reproductive health, and highlight the importance of research on the effects of hypertension on gonadal inflammation and lymphatics.
高血压是导致终末器官损伤的最常见疾病之一，尤其会影响心脏、肾脏、大脑和眼睛。许多研究评估了高血压与男性和女性性功能障碍之间的关联。高血压对男性的有害影响包括勃起功能障碍、精液量减少、精子计数和活力下降以及精子形态异常。同样，患有高血压的女性表现为阴道润滑减少、性高潮减少以及妊娠并发症导致胎儿和产妇发病率和死亡率增加。高血压对男性和女性生育能力的不良影响归因于激素失衡和性腺血管变化。然而，关于高血压对性腺在分子基础上更详细影响的机制研究仍然很少。因此，本综述的目的是探讨和总结高血压对生殖健康的影响，并强调研究高血压对性腺炎症和淋巴管的影响的重要性。
