Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Research Group on Metabolism, Nutrition and Strength Training, Department of Physical Education, Federal University of Parana, Curitiba, Brazil.
Physiol Genomics. 2021 Feb 1;53(2):47-50. doi: 10.1152/physiolgenomics.00118.2020. Epub 2020 Dec 21.
Combat sports are an intermittent sport, with mixed anaerobic and aerobic energy production. Here, we investigated whether the polymorphisms that have been previously suggested as genetic markers for endurance or power phenotypes were associated with combat-sport athletic status. A total of 23 previously reported performance-related polymorphisms were examined in a cohort of 1,129 Brazilian individuals (164 combat-sport athletes and 965 controls), using a case-control association study. We found that the GA-binding protein transcription factor subunit beta 1 () gene (also known as nuclear respiratory factor 2; ) was associated with athletic status, with the minor G (rs7181866) and T (rs8031031) alleles overrepresented in athletes ( ≤ 0.003), especially among world-class athletes ( ≤ 0.0002). These findings indicate that single-nucleotide polymorphisms (SNPs) within the gene increase the likelihood of an individual being a combat-sport athlete, possibly because of a better mitochondrial response to intermittent exercises.
格斗运动是一种间歇性运动，混合了无氧和有氧能量产生。在这里，我们研究了先前被认为是耐力或力量表型遗传标志物的多态性是否与格斗运动运动员的状态有关。在一项由 1129 名巴西人（164 名格斗运动员和 965 名对照者）组成的队列中，使用病例对照关联研究，检查了总共 23 种先前报道的与表现相关的多态性。我们发现，GA 结合蛋白转录因子亚基β1（）基因（也称为核呼吸因子 2；）与运动状态相关，运动员中次要 G（rs7181866）和 T（rs8031031）等位基因的出现频率更高（≤0.003），尤其是在世界级运动员中（≤0.0002）。这些发现表明，基因内的单核苷酸多态性（SNPs）增加了个体成为格斗运动员的可能性，可能是因为间歇运动对线粒体的反应更好。
