先天性心脏病与基因多态性的关联：系统评价和荟萃分析。
Association between congenital heart disease and gene polymorphisms: systematic review and meta-analysis.
机构信息
Multidisciplinary Academic Division of Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco, Mexico.
Multidisciplinary Academic Division of Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, Mexico.
出版信息
Biomark Med. 2020 Dec;14(18):1747-1757. doi: 10.2217/bmm-2020-0190.
To analyze the association of gene with congenital heart disease (CHD), and to determine if the variants rs703752, rs3729753 and rs2277923 increase the risk for developing CHD. PubMed, EBSCO and Web of Science databases were screened to identify eligible studies. Through a comprehensive meta-analysis software, the association between gene variants and susceptibility of CHD was calculated by pooled odd ratio (ORs) and 95% CI. We observed that the allelic model of rs703752 and rs2277923 increased the risk in the overall population: OR = 1.24; 95% CI: 1.00-1.55; Z p-value = 0.049; OR = 1.18; 95% CI: 0.01-1.37; Z p-value = 0.036; respectively. Our results suggested that the rs703752 and rs2277923 polymorphisms of the gene are associated with CHD.
分析基因与先天性心脏病（CHD）的关联，并确定 rs703752、rs3729753 和 rs2277923 等变异是否增加 CHD 的发病风险。通过筛选 PubMed、EBSCO 和 Web of Science 数据库，确定了符合条件的研究。通过综合荟萃分析软件，计算了基因变异与 CHD 易感性之间的关联，采用合并优势比（ORs）和 95%置信区间（95%CI）进行评估。我们观察到 rs703752 和 rs2277923 的等位基因模型增加了总体人群的患病风险：OR=1.24；95%CI：1.00-1.55；Z p 值=0.049；OR=1.18；95%CI：0.01-1.37；Z p 值=0.036。我们的结果表明，基因的 rs703752 和 rs2277923 多态性与 CHD 相关。
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