EMC 介导的膜蛋白生物发生
Membrane protein biogenesis by the EMC.
机构信息
School of Biochemistry, University of Bristol, Bristol, UK.
Department of Biochemistry, University of Oxford, Oxford, UK.
出版信息
EMBO J. 2021 Jan 15;40(2):e107407. doi: 10.15252/embj.2020107407. Epub 2020 Dec 21.
Abstract
The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a decade ago in a genetic screen for ER protein homeostasis. The EMC inserts transmembrane domains (TMDs) with limited hydrophobicity. Two recent cryo-EM structures, and a third model based on partial high- and low-resolution structures, suggest how this is accomplished.
摘要
内质网（ER）膜蛋白复合物（EMC）在十多年前的 ER 蛋白动态平衡的遗传筛选中被鉴定出来。EMC 插入具有有限疏水性的跨膜结构域（TMD）。最近的两项冷冻电镜结构和基于部分高、低分辨率结构的第三个模型，提出了完成这一过程的机制。
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