Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Division of Pulmonary Medicine, Department of Internal Medicine, Lukang Christian Hospital, Changhua, Taiwan.
Respir Physiol Neurobiol. 2021 Mar;285:103603. doi: 10.1016/j.resp.2020.103603. Epub 2020 Dec 25.
Resolvin is a checkpoint controller in inflammation. Matrix metalloproteinase-9 (MMP-9) is an airway remodeling regulator. We evaluated the levels of resolvin and MMP-9 protein in the serum and exhaled breath condensate (EBC) before and after continuous positive airway pressure (CPAP) treatment.
We enrolled 20 non-OSA snorers and 40 patients with moderate to severe OSA scheduled for CPAP treatment. ELISA was used to assess resolvin and MMP-9 levels in the serum and EBC. All patients underwent sleep assessment at baseline and 3 months after CPAP.
There was no between-group difference; moreover, there were no differences in the pre- and post-treatment serum levels of resolvin and MMP-9 in patients with OSA. Compared with non-OSA snorers, patients with OSA had lower resolvin and higher MMP-9 levels in the EBC. After CPAP treatment, the EBC levels of resolvin and MMP-9 in patients with OSA returned to normal.
Successful OSA treatment by CPAP can normalize EBC levels of resolvin and MMP-9.
消退素是炎症的一个检查点控制器。基质金属蛋白酶-9（MMP-9）是气道重塑的调节因子。我们评估了持续气道正压通气（CPAP）治疗前后血清和呼出气冷凝物（EBC）中消退素和 MMP-9 蛋白的水平。
我们纳入了 20 名非阻塞性睡眠呼吸暂停（OSA）打鼾者和 40 名中重度 OSA 患者，这些患者计划接受 CPAP 治疗。酶联免疫吸附试验（ELISA）用于评估血清和 EBC 中消退素和 MMP-9 的水平。所有患者在基线和 CPAP 治疗 3 个月后均进行睡眠评估。
组间无差异；此外，OSA 患者治疗前后血清中消退素和 MMP-9 水平无差异。与非 OSA 打鼾者相比，OSA 患者 EBC 中的消退素水平较低，MMP-9 水平较高。经 CPAP 治疗后，OSA 患者 EBC 中的消退素和 MMP-9 水平恢复正常。
CPAP 治疗 OSA 成功可使 EBC 中的消退素和 MMP-9 水平恢复正常。
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