Guangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment; Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China.
State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guanghou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China.
Environ Pollut. 2021 Feb 1;270:116211. doi: 10.1016/j.envpol.2020.116211. Epub 2020 Dec 2.
Evidence concerning effects of ambient air pollution on homocysteine (HCY) metabolism is scarce. We aimed to explore the associations between ambient particulate matter (PM) exposure and the HCY metabolism markers and to evaluate effect modifications by folate, vitamin B, and methylenetetrahyfrofolate reductase (MTHFR) C677T gene polymorphism. Between December 1, 2017 and January 5, 2018, we conducted a panel study in 88 young college students in Guangzhou, China, and received 5 rounds of health examinations. Real-time concentrations of PMs with aerodynamic diameter ≤2.5 (PM), ≤1.0 (PM), and ≤0.1 (PM) were monitored, and the serum HCY metabolism markers (i.e., HCY, S-Adenosylhomocysteine [SAH], and S-Adenosylmethionine [SAM]) were repeatedly measured. We applied linear mixed effect models combined with a distributed lag model to evaluate the associations of PMs with the HCY metabolism markers. We also explored effect modifications of folate, vitamin B, and the MTHFR C677T polymorphism on the associations. We observed that higher concentrations of PM and PM were associated with higher serum levels of HCY, SAH, SAM, and SAM/SAH ratio (e.g., a 10 μg/m increase in PM during lag 0 day and lag 5 day was significantly associated with 1.3-19.4%, 1.3-28.2%, 6.2-64.4%, and 4.8-28.2% increase in HCY, SAH, SAM, and SAM/SAH ratio, respectively). In addition, we observed that the associations of PM with the HCY metabolism markers were stronger in participants with lower B vitamins levels. This study demonstrated that short-term exposure to PM and PM was deleteriously associated with the HCY metabolism markers, especially in people with lower B vitamins levels.
有关环境空气污染对同型半胱氨酸（HCY）代谢影响的证据很少。我们旨在探索环境颗粒物（PM）暴露与 HCY 代谢标志物之间的关联，并评估叶酸、维生素 B 和亚甲基四氢叶酸还原酶（MTHFR）C677T 基因多态性的作用修饰。2017 年 12 月 1 日至 2018 年 1 月 5 日，我们在中国广州对 88 名年轻大学生进行了一项面板研究，并进行了 5 轮健康检查。实时监测了空气动力学直径≤2.5（PM）、≤1.0（PM）和≤0.1（PM）的 PM 浓度，并反复测量了血清 HCY 代谢标志物（即 HCY、S-腺苷同型半胱氨酸[SAH]和 S-腺苷甲硫氨酸[SAM]）。我们应用线性混合效应模型结合分布式滞后模型来评估 PM 与 HCY 代谢标志物之间的关联。我们还探讨了叶酸、维生素 B 和 MTHFR C677T 多态性对这些关联的作用修饰。我们观察到，较高浓度的 PM 和 PM 与血清 HCY、SAH、SAM 和 SAM/SAH 比值升高有关（例如，PM 在滞后 0 天和滞后 5 天每增加 10μg/m，与 HCY、SAH、SAM 和 SAM/SAH 比值分别增加 1.3-19.4%、1.3-28.2%、6.2-64.4%和 4.8-28.2%）。此外，我们还观察到，PM 与 HCY 代谢标志物之间的关联在 B 族维生素水平较低的参与者中更强。这项研究表明，短期暴露于 PM 和 PM 与 HCY 代谢标志物呈有害相关，尤其是在 B 族维生素水平较低的人群中。
