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胎儿超声心动图的适应证与异常检查结果和高龄产妇之间缺乏关联:一项横断面研究——胎儿异常超声心动图。

Fetal Echocardiography Indications and Lack of Association between Abnormal Exams and Advanced Maternal Age: A Cross-Sectional Study - Fetal Abnormal Echocardiography.

机构信息

Universidade Federal Fluminense, Niterói, RJ, Brazil.

Universidade Federal de São Carlos, São Carlos, SP, Brazil.

出版信息

Rev Bras Ginecol Obstet. 2020 Dec;42(12):805-810. doi: 10.1055/s-0040-1718445. Epub 2020 Dec 21.

Abstract

OBJECTIVE

To analyze the most frequent referrals for fetal echocardiography, including advanced maternal age and its association with abnormal results.

METHODS

We included all pregnant women referred to perform fetal echocardiography (gestational age 22-32 weeks) in 2 health centers in Rio de Janeiro, from June 2015 to June 2016. Advanced maternal age was considered when age was > 35 years at the time of delivery). Referral reasons and results were recorded, according to the Brazilian Fetal Cardiology Statement. Crude and adjusted prevalence ratios were calculated (Poisson regression). We considered  < 0.05 as significant.

RESULTS

A total of 1,221 tests were analyzed. Abnormal fetal echocardiography was observed in 14.82% of the cases. The most frequent abnormalities were interventricular septal defect (6.39%), septal hypertrophy (3.35%) and atrioventricular septal defect (1.14%). Routine exams were performed in 559 women, 289 were referred for advanced maternal age and 373 were referred according to the Brazilian Fetal Cardiology Statement criteria. An obstetric ultrasound suggesting fetal cardiac abnormality, maternal diabetes, increased nuchal translucency, and obstetric ultrasound suggesting a noncardiac abnormality were strongly associated with an abnormal fetal echocardiography. Abnormal results were not more frequent in women with advanced maternal age when compared with the rest of the study group.

CONCLUSIONS

It was observed that routine exams and advanced maternal age referrals were very frequent. Those exams were not associated to fetal echocardiography abnormalities. In this scenario, when the obstetric ultrasound suggests a fetal cardiac abnormality, the fetal echocardiography probably is abnormal. Therefore, obstetric ultrasound is a good screening method.

摘要

目的

分析胎儿超声心动图最常见的转诊原因,包括高龄产妇及其与异常结果的关系。

方法

我们纳入了 2015 年 6 月至 2016 年 6 月在里约热内卢的 2 个医疗中心进行胎儿超声心动图检查(妊娠 22-32 周)的所有孕妇。分娩时年龄>35 岁被认为是高龄产妇。根据巴西胎儿心脏病学声明记录转诊原因和结果。计算了粗患病率比和调整后患病率比(泊松回归)。我们认为 P 值<0.05 为差异有统计学意义。

结果

共分析了 1221 次检查。胎儿超声心动图异常的发生率为 14.82%。最常见的异常为室间隔缺损(6.39%)、间隔肥厚(3.35%)和房室间隔缺损(1.14%)。对 559 名孕妇进行了常规检查,289 名因高龄产妇转诊,373 名根据巴西胎儿心脏病学声明标准转诊。超声提示胎儿心脏异常、母亲糖尿病、颈后透明带增加和超声提示非心脏异常与胎儿超声心动图异常强烈相关。与研究组的其他女性相比,高龄产妇的异常结果并不更为常见。

结论

我们发现常规检查和高龄产妇转诊非常常见。这些检查与胎儿超声心动图异常无关。在此情况下,如果产科超声提示胎儿心脏异常,则胎儿超声心动图可能异常。因此,产科超声是一种很好的筛查方法。

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Brazilian Fetal Cardiology Guidelines - 2019.《巴西胎儿心脏病学指南 - 2019》
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Prenatal screening for structural congenital heart disease.先天性结构性心脏病的产前筛查。
Nat Rev Cardiol. 2014 Jun;11(6):323-34. doi: 10.1038/nrcardio.2014.34. Epub 2014 Mar 25.

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