Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Pediatr Obes. 2021 May;16(5):e12742. doi: 10.1111/ijpo.12742. Epub 2020 Dec 21.
Research findings of the association and its pattern between obesity and psychiatric/psychological comorbidities are not consistent across the types of comorbidities or the study subgroups.
We aimed to perform meta-analysis of cross-sectional studies and longitudinal studies analysing obesity as a risk factor for conduct disorder in order to assess the association between child/adolescent overweight/obesity and conduct disorder.
Systematic literature search, study selection and data extraction were performed independently by the two authors. Data were analysed by Comprehensive Meta-analysis software.
Analysis of 13 high-quality cross-sectional studies including 79 027 children and adolescents indicated a significant association between overweight/obesity and conduct disorder among children and adolescents (OR 1.32 [95% CI, 1.18-1.49], I = 86.68), with no publication bias. Subgroup analyses yielded a significant difference (P < .01) between boys and girls. Analysis of four low- to moderate-quality longitudinal studies (OR 1.11 [95% CI, 0.89-1.38], I = 57.69) showed no prospective association between overweight/obesity and conduct disorder. Subgroup analysis according to gender revealed a significant positive association for boys and negative association for girls.
Based on the high-quality cross-sectional data, overweight and obesity are associated with conduct disorder among children and adolescents, affecting boys more frequently than girls. Results of the longitudinal analysis indicated possible association in boys, while girls seem to be protected from conduct disorder. However, these results are very unreliable, indicating the need of well-designed longitudinal studies to elucidate the pattern of association between these disorders.
肥胖与精神科/心理共病之间的关联及其模式的研究结果在共病类型或研究亚组之间不一致。
我们旨在对分析肥胖作为品行障碍风险因素的横断面研究和纵向研究进行荟萃分析，以评估儿童/青少年超重/肥胖与品行障碍之间的关联。
两位作者独立进行系统文献检索、研究选择和数据提取。使用 Comprehensive Meta-analysis 软件进行数据分析。
对包括 79027 名儿童和青少年在内的 13 项高质量横断面研究进行分析表明，超重/肥胖与儿童和青少年品行障碍之间存在显著关联（OR 1.32 [95% CI，1.18-1.49]，I = 86.68），无发表偏倚。亚组分析显示，男孩和女孩之间存在显著差异（P <.01）。对四项低至中质量的纵向研究（OR 1.11 [95% CI，0.89-1.38]，I = 57.69）进行分析显示，超重/肥胖与品行障碍之间无前瞻性关联。根据性别进行的亚组分析显示，男孩呈显著正相关，女孩呈显著负相关。
基于高质量的横断面数据，超重和肥胖与儿童和青少年的品行障碍有关，男孩比女孩更频繁地受到影响。纵向分析的结果表明男孩可能存在关联，而女孩似乎免受品行障碍的影响。然而，这些结果非常不可靠，表明需要进行精心设计的纵向研究来阐明这些疾病之间关联的模式。
