Alves Javier, Barrientos Gema, Toro Víctor, Grijota Francisco Javier, Muñoz Diego, Maynar Marcos
Department of Sport Science, Faculty of Education, Pontifical University of Salamanca, C/Henry Collet, 52-70, CP, 37007 Salamanca, Spain.
Department of Physiology, Faculty of Sports Science Faculty, University of Extremadura, University Avenue, s/n CP, 10003 Cáceres, Spain.
Int J Environ Res Public Health. 2020 Dec 17;17(24):9473. doi: 10.3390/ijerph17249473.
Several essential trace minerals play an important role in the endocrine system; however, toxic trace minerals have a disruptive effect. The aim of this research was to determine basal concentrations and the possible correlations between trace minerals in plasma and several plasma hormones in runners. Sixty high-level male endurance runners (21 ± 3 years; 1.77 ± 0.05 m; 64.97 ± 7.36 kg) participated in the present study. Plasma hormones were analyzed using an enzyme-linked immunosorbent assay (ELISA) and plasma trace minerals were analyzed with inductively coupled plasma mass spectrometry (ICP-MS). Correlations and simple linear regression were used to assess the association between trace minerals and hormones. Plasma testosterone concentrations were inversely correlated with manganese (r = -0.543; β = -0.410; < 0.01), selenium (r = -0.292; β = -0.024; < 0.05), vanadium (r = -0.406; β = -1.278; < 0.01), arsenic (r = -0.336; β = -0.142; < 0.05), and lead (r = -0.385; β = -0.418; < 0.01). Plasma luteinizing hormone (LH) levels were positively correlated with arsenic (r = 0.298; β = 0.327; < 0.05) and cesium (r = 0.305; β = 2.272; < 0.05), and negatively correlated with vanadium (r = -0.303; β = -2.467; < 0.05). Moreover, cortisol concentrations showed significant positive correlations with cadmium (r = 0.291; β = 209.01; < 0.05). Finally, insulin concentrations were inversely related to vanadium (r = -0.359; β = -3.982; < 0.05). In conclusion, endurance runners living in areas with high environmental levels of toxic minerals should check their concentrations of anabolic hormones.
几种必需的微量矿物质在内分泌系统中发挥着重要作用；然而，有毒微量矿物质具有破坏作用。本研究的目的是确定跑步者血浆中微量矿物质的基础浓度以及它们与几种血浆激素之间的可能相关性。60名高水平男性耐力跑者（21±3岁；身高1.77±0.05米；体重64.97±7.36千克）参与了本研究。使用酶联免疫吸附测定法（ELISA）分析血浆激素，并用电感耦合等离子体质谱法（ICP-MS）分析血浆微量矿物质。采用相关性分析和简单线性回归来评估微量矿物质与激素之间的关联。血浆睾酮浓度与锰（r = -0.543；β = -0.410；P < 0.01）、硒（r = -0.292；β = -0.024；P < 0.05）、钒（r = -0.406；β = -1.278；P < 0.01）、砷（r = -0.336；β = -0.142；P < 0.05）和铅（r = -0.385；β = -0.418；P < 0.01）呈负相关。血浆黄体生成素（LH）水平与砷（r = 0.298；β = 0.327；P < 0.05）和铯（r = 0.305；β = 2.272；P < 0.05）呈正相关，与钒（r = -0.303；β = -2.467；P < 0.05）呈负相关。此外，皮质醇浓度与镉呈显著正相关（r = 0.291；β = 209.01；P < 0.05）。最后，胰岛素浓度与钒呈负相关（r = -0.359；β = -3.982；P < 0.05）。总之，生活在有毒矿物质环境水平较高地区的耐力跑者应检查其合成代谢激素的浓度。
