Department of pediatric intensive care, The Edmond and Lily Safra Children's Hospital, The Chaim Sheba Medical Center, Tel Hashomer, Israel.
The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Perfusion. 2022 Mar;37(2):113-122. doi: 10.1177/0267659120974324. Epub 2020 Dec 21.
Therapeutic plasma exchange in children is increasingly recognized as a life-saving treatment and is challenged by some technical considerations. As extracorporeal membrane oxygenation has been used for nearly half a century for refractory reversible respiratory and/or cardiac failure in both pediatric and adult populations, it may serve as an extracorporeal platform for therapeutic plasma exchange. It is most commonly described in patients with sepsis with multiple organ failure or thrombocytopenia associated multi organ failure. Additional pathophysiological processes of inflammatory and immunological storms might benefit from the combination of extracorporeal membrane oxygenation and plasma exchange. This is a nonmethodological review of English-language reports of therapeutic plasma exchange performed in patients supported by extracorporeal membrane oxygenation, both pediatric and adult, searching six databases, MEDLINE, Clinical Key, GOOGLE SCHOLAR, CINAHL, Cochrane library, and EMBASE.
儿童治疗性血浆置换越来越被认为是一种救命的治疗方法，但也受到一些技术因素的挑战。由于体外膜肺氧合（ECMO）近半个世纪以来一直被用于儿科和成人患者难治性可逆性呼吸和/或心脏衰竭，它可以作为治疗性血浆置换的体外平台。它最常用于伴有多器官衰竭的脓毒症或与多器官衰竭相关的血小板减少症患者。炎症和免疫风暴的其他病理生理过程可能受益于体外膜肺氧合和血浆置换的联合应用。这是对支持体外膜肺氧合的儿童和成人患者进行治疗性血浆置换的英文报告的非方法学综述，检索了 6 个数据库：MEDLINE、Clinical Key、GOOGLE SCHOLAR、CINAHL、Cochrane 图书馆和 EMBASE。
