SIR Institute for Pharmacy Practice and Policy, Theda Mansholtstraat 5b, 331 JE, Leiden, the Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB, Utrecht, the Netherlands.
Radboud University Medical Center, Radboud Institute for Health Sciences (RIHS), P.O. Box 9101, 148 RIHS, 6500 HB, Nijmegen, the Netherlands; Department of Primary and Community Care, P.O. Box 9101, 120, ELG, 6500 HB, Nijmegen, the Netherlands.
Res Social Adm Pharm. 2022 Mar;18(3):2424-2431. doi: 10.1016/j.sapharm.2020.11.012. Epub 2020 Nov 21.
Drug shortages affect health systems worldwide. Research in community pharmacy has focused on the nature, extent and impact of these shortages on patients and pharmacists. However, pharmacists' moral reasoning in situations of drug shortages has not been addressed.
To explore the moral reasoning perspectives of Dutch community pharmacists in situations of drug shortages.
An electronic survey was developed around three drug shortage scenarios with a varying impact on patient outcomes: a Contraceptive, a Parkinson's and an Osteoporosis scenario. Pharmacists rated the likelihood of nine handling options and rated and ranked 13 considerations that may have played a role therein. The considerations represented three moral reasoning perspectives (MRPs): a business orientation (BO), a rules and regulations (RR), and a professional ethics (PE) MRP. Principle component analysis (PCA) was used to investigate construct validity of the MRPs. MRP rating and MRP ranking scores measured the relative importance of the different MRPs of pharmacists in the three shortages.
Results from 267 Pharmacists were obtained. They reported mostly similar handling in the three shortages, except for the likelihood to make agreements with prescribers or other pharmacists and regarding the decision to import a product. The PCA analysis confirmed the three MRPs that accounted for 29% of variance in the data. Both the MRP rating and especially the MRP ranking scores indicated that PE-MRP considerations were most influential on pharmacists' intended handling of the shortages. In the Contraceptive and the Osteoporosis scenarios, the relative importance of a BO-MRP was higher than in the Parkinson's scenario.
Pharmacists predominantly reason with a PE-MRP when handling drug shortages. However, this perspective can be compromised when the drug shortage is perceived to have a lower impact on patient outcomes and when alternative drugs or therapy are expensive.
药品短缺影响着全球的卫生系统。社区药房的研究集中在这些短缺对患者和药剂师的性质、程度和影响上。然而,药剂师在药品短缺情况下的道德推理尚未得到解决。
探讨荷兰社区药剂师在药品短缺情况下的道德推理视角。
围绕三种对患者结局影响不同的药品短缺情况设计了电子调查:一种避孕药、一种帕金森病和一种骨质疏松症情况。药剂师对九种处理方案的可能性进行了评分,并对可能在其中发挥作用的十三种考虑因素进行了评分和排序。这些考虑因素代表了三种道德推理视角(MRP):商业导向(BO)、规则和条例(RR)和职业道德(PE)MRP。主成分分析(PCA)用于研究 MRP 的结构效度。MRP 评分和 MRP 排名分数衡量了药剂师在三种短缺情况下不同 MRP 的相对重要性。
共获得 267 名药剂师的结果。他们报告说,除了与处方医生或其他药剂师达成协议以及决定进口产品的可能性外,在三种短缺情况下的处理方式大多相似。PCA 分析证实了三个可以解释数据中 29%差异的 MRP。MRP 评分和特别是 MRP 排名分数表明,PE-MRP 考虑因素对药剂师处理短缺的预期处理方式最具影响力。在避孕药和骨质疏松症情况下,BO-MRP 的相对重要性高于帕金森病情况。
药剂师在处理药品短缺时主要采用 PE-MRP 进行推理。然而,当药品短缺被认为对患者结局的影响较低且替代药物或疗法昂贵时,这种观点可能会受到影响。