2014-2018 年台湾地区 HIV 感染者人类疱疹病毒 8 感染的血清流行病学研究。

Seroepidemiology of the human herpesvirus 8 infection among people living with HIV in Taiwan, 2014-2018.

机构信息

Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin County, Taiwan; Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

出版信息

J Microbiol Immunol Infect. 2021 Oct;54(5):934-943. doi: 10.1016/j.jmii.2020.11.005. Epub 2020 Dec 9.

DOI:10.1016/j.jmii.2020.11.005

PMID:33349600

Abstract

BACKGROUND

Human herpesvirus type 8 (HHV-8) can be transmitted through unprotected sex as HIV. We aimed to investigate the seroincidence of HHV-8 and associated factors among people living with HIV (PLWH).

METHODS

From 2014 to 2018, blood samples of PLWH on the first date of HIV care were determined for antibodies against HHV-8. Individuals testing HHV-8-seronegative at baseline were followed for at least four months to estimate the annual seroconversion rate. To identify the factors associated with HHV-8 seroconversion, we compared the clinical characteristics between seroconverters and non-seroconverters who were matched for observation duration.

RESULTS

The HHV-8 seroprevalence increased from 8.1% in 2014 to 20.0% in 2018. HHV-8 seroconversion occurred in 154 (14.7%) PLWH after a total of 2652.16 person-years of follow-up (PYFU), resulting in an overall incidence rate of 5.62 per 100 PYFU, which increased from 3.20 to 6.84 per 100 PYFU during the study period. HHV-8 seroconverters were less likely to have chronic hepatitis B virus (HBV) infection (1.9% vs 10.6%) and more likely to be antiretroviral-naïve on entry into care (87.7% vs 75.4%) (both p < 0.05). In multivariate logistic analysis, men who have sex with men (MSM) (adjusted odds ratio [aOR], 2.22; 95% CI, 1.01-4.86), being antiretroviral-naïve (aOR, 2.91; 95% CI, 1.27-6.67), and chronic HBV infection (aOR, 0.13; 95% CI, 0.03-0.61) at baseline were associated with HHV-8 seroconversion.

CONCLUSIONS

An increasing trend of HHV-8 infection was observed among PLWH in Taiwan between 2014 and 2018. MSM and being antiretroviral-naïve were associated with higher risk for HHV-8 seroconversion.

摘要

背景

人类疱疹病毒 8 型（HHV-8）可通过无保护的性行为传播，就像 HIV 一样。我们旨在研究人类疱疹病毒 8 型（HHV-8）在艾滋病毒感染者（PLWH）中的血清流行率及其相关因素。

方法

从 2014 年到 2018 年，对首次接受艾滋病毒护理的 PLWH 的血液样本进行了针对 HHV-8 抗体的检测。在基线时检测为 HHV-8 血清阴性的个体至少随访四个月以估计年血清转化率。为了确定与 HHV-8 血清转化率相关的因素，我们比较了血清转化率与按观察时间匹配的非血清转化率个体的临床特征。

结果

HHV-8 的血清流行率从 2014 年的 8.1%上升到 2018 年的 20.0%。在总共 2652.16 人年的随访（PYFU）后，154 名 PLWH（14.7%）发生了 HHV-8 血清转换，总发生率为每 100 PYFU 5.62 例，在研究期间从每 100 PYFU 3.20 例增加到 6.84 例。HHV-8 血清转化率较低的人更不可能患有慢性乙型肝炎病毒（HBV）感染（1.9%比 10.6%），更有可能在开始接受护理时为抗逆转录病毒初治者（87.7%比 75.4%）（均 P<0.05）。在多变量逻辑分析中，男男性行为者（MSM）（调整优势比 [aOR]，2.22；95%CI，1.01-4.86）、抗逆转录病毒初治（aOR，2.91；95%CI，1.27-6.67）和慢性 HBV 感染（aOR，0.13；95%CI，0.03-0.61）与 HHV-8 血清转换相关。