Antonelli Incalzi Raffaele, Caraci Filippo, Cuomo Alessandro, Fagiolini Andrea, Ferini Strambi Luigi
Dipartimento di Geriatria, Università Campus Bio-Medico, Roma.
Dipartimento di Scienze del Farmaco, Università di Catania, Catania - Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Italy.
Riv Psichiatr. 2020 Nov-Dec;55(6):371-379. doi: 10.1708/3503.34896.
This paper completes a series of three manuscripts on the clinically relevant evidence of the use of trazodone in major depressive disorder. The first paper provided general clinical guidance on the use of trazodone in major depressive disorder. The second paper evaluated the different clinical scenarios in which trazodone prolonged-release or trazodone Contramid® once-a-day may be more indicated. This third and last paper evaluates the clinically relevant evidence about the use of trazodone in major depressive disorder (MDD) with insomnia.
Medline and Cochrane Library searches were performed using the keywords 'trazodone' AND 'depression' AND 'insomnia', to identify the most relevant literature on the use of trazodone in patients with MDD and insomnia. European and the United States prescribing information was reviewed as well. More weight was given to the information that was deemed as most relevant for daily clinical practice.
Trazodone is an effective medication for patients with MDD and insomnia.
Trazodone is efficacious for the treatment of a broad array of depressive symptoms and is particularly useful for patients presenting with insomnia as one of the symptoms of depression.
Trazodone improves sleep and depression and is particularly helpful for patients whose symptoms of depression include insomnia.
本文完成了关于曲唑酮在重度抑郁症中应用的临床相关证据的三篇系列文稿。第一篇文稿提供了曲唑酮在重度抑郁症中应用的一般临床指导。第二篇文稿评估了更适合使用曲唑酮缓释片或每日一次的曲唑酮控释片的不同临床情况。这第三篇也是最后一篇文稿评估了曲唑酮在伴有失眠的重度抑郁症（MDD）中应用的临床相关证据。
使用关键词“曲唑酮”、“抑郁症”和“失眠”在Medline和Cochrane图书馆进行检索，以确定关于曲唑酮在MDD伴失眠患者中应用的最相关文献。还查阅了欧洲和美国的处方信息。对被认为与日常临床实践最相关的信息给予了更多权重。
曲唑酮对MDD伴失眠患者是一种有效的药物。
曲唑酮对治疗多种抑郁症状有效，对以失眠作为抑郁症状之一的患者尤其有用。
曲唑酮可改善睡眠和抑郁，对抑郁症状包括失眠的患者特别有帮助。
