苔藓抑素1拮抗12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯在人结肠癌细胞中的终末分化作用。
Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell.
作者信息
McBain J A, Pettit G R, Mueller G C
机构信息
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
出版信息
Carcinogenesis. 1988 Jan;9(1):123-9. doi: 10.1093/carcin/9.1.123.
12-O-Tetradecanoylphorbol-13-acetate (TPA), a highly active representative of the tumor-promoting phorbol esters, induces a rapid terminal differentiation of a human colon cancer cell line. Bryostatin 1, a macrocyclic lactone, completely counteracts this effect of TPA and promotes continued replication. The observed responses provide a system for identifying cellular processes which are involved in the induced terminal differentiation of human colon cancer cells.
12 - 十四酰佛波醇 - 13 - 乙酸酯（TPA）是促癌佛波酯中一种高活性代表物，可诱导人结肠癌细胞系快速终末分化。苔藓抑素1是一种大环内酯，能完全抵消TPA的这种作用并促进细胞持续复制。观察到的这些反应提供了一个用于识别参与人结肠癌细胞诱导终末分化的细胞过程的系统。
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