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Towards selective pharmacological modulation of protein kinase C--opportunities for the development of novel antineoplastic agents.

作者信息

Gescher A

出版信息

Br J Cancer. 1992 Jul;66(1):10-9. doi: 10.1038/bjc.1992.209.

DOI:10.1038/bjc.1992.209
PMID:1637658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1977896/
Abstract
摘要

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Towards selective pharmacological modulation of protein kinase C--opportunities for the development of novel antineoplastic agents.迈向蛋白激酶C的选择性药理学调控——新型抗肿瘤药物研发的机遇
Br J Cancer. 1992 Jul;66(1):10-9. doi: 10.1038/bjc.1992.209.
2
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Early response gene signalling in bryostatin-stimulated primary B chronic lymphocytic leukaemia cells in vitro.体外苔藓抑素刺激的原发性B慢性淋巴细胞白血病细胞中的早期反应基因信号传导
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9
Emerging drug treatments for solid tumours.实体瘤的新兴药物治疗方法。
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Establishment of a murine leukaemia cell line resistant to the growth-inhibitory effect of bryostatin 1.建立对苔藓抑素1生长抑制作用具有抗性的小鼠白血病细胞系。
Br J Cancer. 1994 Oct;70(4):573-8. doi: 10.1038/bjc.1994.353.

本文引用的文献

1
Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.氯丙嗪、丁卡因及其他与磷脂相互作用药物对钙激活的、磷脂依赖性蛋白激酶的抑制作用。
J Biol Chem. 1980 Sep 25;255(18):8378-80.
2
Modes of inhibition by acylcarnitines, adriamycin and trifluoperazine of cardiac phospholipid-sensitive calcium-dependent protein kinase.酰基肉碱、阿霉素和三氟拉嗪对心脏磷脂敏感性钙依赖性蛋白激酶的抑制模式。
Biochem Pharmacol. 1983 Apr 1;32(7):1259-65. doi: 10.1016/0006-2952(83)90280-0.
3
Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane.佛波酯增加了与质膜相关的Ca2+、磷脂依赖性蛋白激酶的量。
Nature. 1983;301(5901):621-3. doi: 10.1038/301621a0.
4
Phorbol diesters and cellular differentiation.佛波酯与细胞分化
J Natl Cancer Inst. 1984 Nov;73(5):1013-9.
5
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.异喹啉磺酰胺，新型强效环核苷酸依赖性蛋白激酶和蛋白激酶C抑制剂。
Biochemistry. 1984 Oct 9;23(21):5036-41. doi: 10.1021/bi00316a032.
6
Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells.佛波酯处理的3T3细胞中钙敏感、磷脂依赖性蛋白激酶活性的消失。
Biochem Biophys Res Commun. 1984 May 16;120(3):1053-9. doi: 10.1016/s0006-291x(84)80213-2.
7
Antineoplastic components of marine animals.海洋动物的抗肿瘤成分。
Nature. 1970 Aug 29;227(5261):962-3. doi: 10.1038/227962a0.
8
Bryostatins: potent, new mitogens that mimic phorbol ester tumor promoters.苔藓抑素：强效新型有丝分裂原，可模拟佛波酯肿瘤启动子
Biochem Biophys Res Commun. 1985 Nov 15;132(3):939-45. doi: 10.1016/0006-291x(85)91898-4.
9
Protein kinase C contains a pseudosubstrate prototope in its regulatory domain.蛋白激酶C在其调节结构域中含有一个假底物原基。
Science. 1987 Dec 18;238(4834):1726-8. doi: 10.1126/science.3686012.
10
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin.苔藓抑素1是一种蛋白激酶C激活剂，可抑制佛波酯在SENCAR小鼠皮肤中的肿瘤促进作用。
Carcinogenesis. 1987 Sep;8(9):1343-6. doi: 10.1093/carcin/8.9.1343.