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Early hematopoietic cell transplantation for familial hemophagocytic lymphohistiocytosis in a regional treatment network in Japan.在日本的区域治疗网络中,对家族性噬血细胞性淋巴组织细胞增多症进行早期造血细胞移植。
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Emapalumab treatment in an ADA-SCID patient with refractory hemophagocytic lymphohistiocytosis-related graft failure and disseminated bacillus Calmette-Guérin infection.依马芦单抗治疗抗腺苷脱氨酶缺乏症严重联合免疫缺陷病患者伴难治性噬血细胞性淋巴组织细胞增生症相关移植物衰竭和播散性卡介苗感染。
Haematologica. 2021 Feb 1;106(2):641-646. doi: 10.3324/haematol.2020.255620.
2
Stem cell transplantation for children with hemophagocytic lymphohistiocytosis: results from the HLH-2004 study.噬血细胞性淋巴组织细胞增生症患儿的干细胞移植:HLH - 2004研究结果
Blood Adv. 2020 Aug 11;4(15):3754-3766. doi: 10.1182/bloodadvances.2020002101.
3
Risk factors for mixed chimerism in children with hemophagocytic lymphohistiocytosis after reduced toxicity conditioning.降低毒性预处理后噬血细胞性淋巴组织细胞增生症患儿混合嵌合体形成的危险因素
Pediatr Blood Cancer. 2020 Sep;67(9):e28523. doi: 10.1002/pbc.28523. Epub 2020 Jul 3.
4
Cell Versus Cytokine - Directed Therapies for Hemophagocytic Lymphohistiocytosis (HLH) in Inborn Errors of Immunity.细胞与细胞因子导向治疗遗传性免疫缺陷相关噬血细胞性淋巴组织细胞增生症(HLH)
Front Immunol. 2020 May 8;11:808. doi: 10.3389/fimmu.2020.00808. eCollection 2020.
5
Early T Cell Activation Metrics Predict Graft-versus-Host Disease in a Humanized Mouse Model of Hematopoietic Stem Cell Transplantation.早期 T 细胞激活标志物可预测造血干细胞移植人源化小鼠模型中的移植物抗宿主病。
J Immunol. 2020 Jul 1;205(1):272-281. doi: 10.4049/jimmunol.2000054. Epub 2020 May 22.
6
Targeted busulfan-based reduced-intensity conditioning and HLA-matched HSCT cure hemophagocytic lymphohistiocytosis.靶向性基于白消安的减低强度预处理和 HLA 匹配 HSCT 可治愈噬血细胞性淋巴组织细胞增生症。
Blood Adv. 2020 May 12;4(9):1998-2010. doi: 10.1182/bloodadvances.2020001748.
7
Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis.埃马珠单抗治疗原发性噬血细胞性淋巴组织细胞增生症患儿。
N Engl J Med. 2020 May 7;382(19):1811-1822. doi: 10.1056/NEJMoa1911326.
8
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function.一种新的疾病,涉及由于 CDC42 功能异常导致的血液系统异常、炎症和 HLH。
J Exp Med. 2019 Dec 2;216(12):2778-2799. doi: 10.1084/jem.20190147. Epub 2019 Oct 10.
9
Ruxolitinib for refractory/relapsed hemophagocytic lymphohistiocytosis.芦可替尼用于难治性/复发性噬血细胞性淋巴组织细胞增生症
Haematologica. 2020 May;105(5):e210-e212. doi: 10.3324/haematol.2019.222471. Epub 2019 Sep 12.
10
Role of interferon-γ in immune-mediated graft failure after allogeneic hematopoietic stem cell transplantation.干扰素-γ 在异基因造血干细胞移植后免疫介导的移植物失败中的作用。
Haematologica. 2019 Nov;104(11):2314-2323. doi: 10.3324/haematol.2019.216101. Epub 2019 Feb 21.

Possible roads to improve hemophagocytic lymphohistiocytosis outcome.

作者信息

Merli Pietro, Jordan Michael B, Locatelli Franco

机构信息

Department of Hematology/Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, Rome, Italy.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

出版信息

Blood Adv. 2020 Dec 22;4(24):6127-6129. doi: 10.1182/bloodadvances.2020003263.

DOI:10.1182/bloodadvances.2020003263
PMID:33351106
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7756988/
Abstract
摘要