白细胞介素-6 水平在镰状细胞病儿童急性胸部综合征时的痰中显著升高。
IL-6 levels are dramatically high in the sputum from children with sickle cell disease during acute chest syndrome.
机构信息
Department of General Pediatrics and Pediatric Infectious Diseases, Reference Center for Sickle Cell Disease, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France.
Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Université de Paris, Imagine Institute, INSERM U1163, Paris, France.
出版信息
Blood Adv. 2020 Dec 22;4(24):6130-6134. doi: 10.1182/bloodadvances.2020003519.
Abstract
Sputum interleukin-6 (IL-6) level is high during acute chest syndrome (ACS) in pediatric sickle cell disease, supporting anti–IL-6 trials. Sputum IL-8, CCL2, and CCL3 levels are also high during ACS, possibly contributing to recruitment of inflammatory cells in the lungs.
摘要
在小儿镰状细胞病的急性胸部综合征（ACS）期间，痰液中的白细胞介素-6（IL-6）水平较高，支持抗-IL-6 试验。在 ACS 期间，痰液中的白细胞介素-8（IL-8）、CCL2 和 CCL3 水平也较高，可能有助于炎症细胞在肺部的募集。
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