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[How long should treatment with tocilizumab be carried out for giant cell arteritis and how should it be ended (discontinue/taper off)?].

作者信息

Henes J

机构信息

Zentrum für Interdisziplinäre Rheumatologie, klinische Immunologie und Autoimmunerkrankungen (INDIRA), Universitätsklinikum Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland.

出版信息

Z Rheumatol. 2021 Mar;80(2):176-179. doi: 10.1007/s00393-020-00947-4. Epub 2020 Dec 22.

DOI:10.1007/s00393-020-00947-4
PMID:33351160
Abstract

The revised S2 guidelines for treatment of giant cell arteritis have recently been published. Glucocorticosteroids remain the standard first line treatment. For severe or relapsing courses of the disease, the IL‑6 antagonist tocilizumab, a potent antibody, is now available as a therapeutic option; however, how long this treatment should be continued after having achieved a stable remission remains a matter of discussion. For patients with a complicated course and a high risk of relapse, a continuous treatment would be the safest way; however, with a milder course of disease for approximately half of the patients, treatment without relapse can be discontinued again.

摘要

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本文引用的文献

1
Trial of Tocilizumab in Giant-Cell Arteritis.托珠单抗治疗巨细胞动脉炎的试验
N Engl J Med. 2017 Oct 12;377(15):1494-1495. doi: 10.1056/NEJMc1711031.