Medical Education Center, Nihon University School of Medicine, Tokyo, Japan.
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Pediatr Int. 2021 Sep;63(9):1087-1094. doi: 10.1111/ped.14585. Epub 2021 Jul 30.
Helicobacter pylori (H. pylori) infection causes various extragastric diseases. Its transmission route has still not been clarified. However, no large-scale studies have examined the extragastric diseases caused by H. pylori in adolescents. This study aimed to examine the association of H. pylori infection with anemia, serum cholesterol levels, physique, and birth delivery method (vaginal or cesarean) in a large number of Japanese adolescents.
From 2016 to 2018, we screened 2,399 adolescents (aged 13-15 years) in their second and third years of junior high school using an enzyme-linked immunosorbent assay-based antibody test. Red blood cells, hemoglobin, hematocrit, total cholesterol, high-density lipoprotein (HDL) cholesterol, and serum antibody levels were measured.
Hemoglobin and hematocrit levels were significantly lower in the H. pylori antibody-positive group than in the H. pylori antibody-negative group in both sexes (boys: P = 0.0004 and 0.0022; girls: P = 0.0019 and 0.0005, respectively). Total cholesterol and non-HDL cholesterol levels were significantly higher in the H. pylori-positive group than in the H. pylori-negative group among boys (P = 0.0370 and 0.0293 respectively). There was no significant difference in body mass index percentile and birth delivery method between the H. pylori-positive and H. pylori-negative groups in both boys and girls.
Among Japanese junior high school students, H. pylori antibody-positive status was associated with anemia in both sexes while total cholesterol and non-HDL cholesterol levels were associated among boys. There was no association between H. pylori antibody status, body mass index percentile, and birth-delivery method.
幽门螺杆菌（H. pylori）感染可引起多种胃外疾病。其传播途径尚未明确。然而，目前尚无大规模研究调查 H. pylori 在青少年中引起的胃外疾病。本研究旨在调查大量日本青少年中 H. pylori 感染与贫血、血清胆固醇水平、体质和分娩方式（阴道分娩或剖宫产）的相关性。
2016 年至 2018 年，我们采用基于酶联免疫吸附试验的抗体检测法对 2399 名（年龄 13-15 岁）初二和初三学生进行了筛查。检测了红细胞、血红蛋白、红细胞压积、总胆固醇、高密度脂蛋白（HDL）胆固醇和血清抗体水平。
男女两性中 H. pylori 抗体阳性组的血红蛋白和红细胞压积水平均显著低于 H. pylori 抗体阴性组（男孩：P = 0.0004 和 0.0022；女孩：P = 0.0019 和 0.0005）。男孩中 H. pylori 阳性组的总胆固醇和非 HDL 胆固醇水平显著高于 H. pylori 阴性组（P = 0.0370 和 0.0293）。男女两性中 H. pylori 阳性组和 H. pylori 阴性组的体质指数百分位数和分娩方式均无显著差异。
在日本初中生中，H. pylori 抗体阳性状态与两性贫血有关，而总胆固醇和非 HDL 胆固醇水平与男孩有关。H. pylori 抗体状态、体质指数百分位数和分娩方式之间无相关性。
