张力下的细胞推动原肠胚形成。

Cells under Tension Drive Gastrulation.

机构信息

Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Studies in Physics and Biology, The Rockefeller University, New York, NY 10065, USA.

Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

出版信息

Dev Cell. 2020 Dec 21;55(6):669-670. doi: 10.1016/j.devcel.2020.11.023.

DOI:10.1016/j.devcel.2020.11.023

PMID:33352138

Abstract

In this issue of Developmental Cell, Muncie et al. describe the generation of gastrulation-like foci of cells within micropatterned colonies of pluripotent stem cells. This demonstration of mechanosensitive β-catenin/Wnt-dependent specification of cell fate during gastrulation illustrates the insights gleaned by placing stem cells in embryo-like mechanical environments.

摘要

本期《发育细胞》中，Muncie 等人描述了在多能干细胞的微图案化细胞集落中产生类原肠胚细胞焦点的过程。这一演示表明，在原肠胚形成过程中，细胞命运的机械敏感性β-catenin/Wnt 依赖性特化，说明了将干细胞置于类似胚胎的机械环境中所获得的见解。