Caldecott-Hazard S
Department of Radiology, University of California, Los Angeles 90024.
Exp Neurol. 1988 Jan;99(1):73-83. doi: 10.1016/0014-4886(88)90128-8.
Interictal changes in locomotor and shock-response behaviors were examined in rats that were kindled unilaterally or bilaterally in the amygdala. 2-Deoxyglucose and naloxone were used to test whether alterations in cerebral glucose metabolism or opioid functioning, respectively, correlated with changes in these behaviors. Bilaterally kindled rats, at 14 to 28 days after their last seizure, displayed increased locomotion (square crossing) in an open field compared with unilaterally kindled or control rats. Bilaterally kindled rats also showed elevated thresholds for the elicitation of a multiple squeak response to tail shocks. Single squeak or tail withdrawal responses to tail shock were not affected by bilateral kindling. Likewise, unilaterally kindled rats did not differ from controls on any of the behavioral measures. Naloxone (10 mg/kg, i.p.) reversed the increase in locomotion and elevation of multiple squeak thresholds in the bilaterally kindled rats. By itself, naloxone did not influence any of the behaviors. Finally, cerebral glucose metabolism was decreased, globally, in the forebrain of the bilaterally kindled rats, and naloxone normalized this change. Cerebral metabolism was not altered in unilaterally kindled rats compared with controls. Thus, changes in cerebral metabolism and opioid functioning may be involved in the mediation of interictal changes in locomotor and emotional behavior in rats.
在单侧或双侧杏仁核点燃的大鼠中，研究了发作间期运动和休克反应行为的变化。分别使用2-脱氧葡萄糖和纳洛酮来测试大脑葡萄糖代谢或阿片类物质功能的改变是否与这些行为的变化相关。在最后一次癫痫发作后的14至28天，双侧点燃的大鼠与单侧点燃或对照大鼠相比，在开放场地中表现出运动增加（穿越方格）。双侧点燃的大鼠对尾部电击引发的多次尖叫反应的阈值也升高。对尾部电击的单次尖叫或尾部退缩反应不受双侧点燃的影响。同样，单侧点燃的大鼠在任何行为指标上与对照大鼠没有差异。纳洛酮（10mg/kg，腹腔注射）逆转了双侧点燃大鼠的运动增加和多次尖叫阈值的升高。单独使用时，纳洛酮不影响任何行为。最后，双侧点燃大鼠的前脑整体脑葡萄糖代谢降低，纳洛酮使这种变化恢复正常。与对照相比，单侧点燃大鼠的脑代谢没有改变。因此，脑代谢和阿片类物质功能的变化可能参与介导大鼠发作间期运动和情绪行为的变化。
