Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology - NTNU, Trondheim, Norway.
Blue Cross Lade Addiction Treatment Centre, Trondheim, Norway.
Alcohol Alcohol. 2021 Aug 30;56(5):565-572. doi: 10.1093/alcalc/agaa133.
The aim of this study was to assess the efficacy of self-administered intranasal oxytocin on alcohol dependence after detoxification.
In a double-blind, randomized, placebo-controlled trial, 38 patients fulfilling the criteria for ICD-10 diagnosis of alcohol dependence received either 8 IU oxytocin or placebo at their own discretion up to thrice daily for 4 weeks, after completing detoxification. Primary outcome was alcohol intake specified as the amount of alcohol consumed, the number of days to relapse into alcohol use and the proportion of subjects relapsing. Secondary outcomes were self-reported symptoms of craving, sleep and mental distress.
There were no significant differences between the oxytocin group and the placebo group in daily alcohol intake in total (mean 1.3 ± 2.9 vs. 2.0 ± 5.0 units; P = 0.63) or on drinking days (mean 8.4 ± 2.7 vs. 7.7 ± 6.0 units; P = 0.76), in the number of days until relapse (P = 0.91) or in the proportion of subjects relapsing (37.5 vs. 41.2%; P = 0.84). Neither were there any statistically significant differences in any other outcomes, except a larger decrease in self-reported nervousness in the oxytocin group (P = 0.022).
The results were inconclusive as to whether intranasal oxytocin reduced the time to relapse, degree of craving or total amount of alcohol consumed after detoxification. However, the oxytocin group had a larger decrease in self-reported nervousness.
本研究旨在评估自我管理的鼻腔内给予催产素对解毒后酒精依赖的疗效。
在一项双盲、随机、安慰剂对照试验中，38 名符合 ICD-10 酒精依赖诊断标准的患者在完成解毒后，自行决定每日最多使用 3 次，每次 8IU 催产素或安慰剂，持续 4 周。主要结局是指定的酒精摄入量，即饮酒量、复发饮酒天数和复发患者比例。次要结局是自我报告的渴望、睡眠和精神困扰症状。
催产素组和安慰剂组在总饮酒量（平均 1.3±2.9 与 2.0±5.0 单位；P=0.63）或饮酒天数（平均 8.4±2.7 与 7.7±6.0 单位；P=0.76）、复发天数（P=0.91）或复发患者比例（37.5%与 41.2%；P=0.84）方面均无显著差异。在其他任何结局方面也没有统计学上的显著差异，除了催产素组自我报告的紧张感有更大的下降（P=0.022）。
鼻腔内给予催产素是否能减少解毒后复发时间、渴望程度或酒精总摄入量的结果尚无定论。然而，催产素组自我报告的紧张感有更大的下降。
