Department of Functional Diagnostics and Kinesiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland.
Department of Physiology and Biochemistry, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland.
Nutrients. 2020 Dec 18;12(12):3874. doi: 10.3390/nu12123874.
A double-blinded, randomized controlled trial.
Surgery is effective in reducing pain intensity in patients with cervical disc disease. However, functional measurements demonstrated that the results have been not satisfactory enough. Thus, rehabilitation programs combined with the supplementation of vitamin D could play an essential role.
The study recruited 30 patients, aged 20 to 70 years, selected for anterior cervical interbody fusion (ACIF). The patients were randomly divided into the placebo (Pl) and vitamin D (3200 IU D3/day) supplemented groups. The functional tests limits of stability (LOS), risk of falls (RFT), postural stability (PST), Romberg test, and foot pressure distribution were performed before supplementation (BS-week 0), five weeks after supplementation (AS-week 5), four weeks after surgery (BSVR-week 9), and 10 weeks after supervising rehabilitation (ASVR-week 19).
The concentration of 25(OH)D3 in the serum, after five weeks of supplementation, was significantly increased, while the Pl group maintained the same. The RFT was significantly reduced after five weeks of vitamin D supplementation. Moreover, a further significant decrease was observed following rehabilitation. In the Pl group, no changes in the RFT were observed. The overall postural stability index (OSI), LOS, and the outcomes of the Romberg test significantly improved in both groups; however, the effects on the OSI were more pronounced in the D3 group at the end of the rehabilitation program.
Our data suggest that vitamin D supplementation positively affected the rehabilitation program in patients implemented four weeks after ACIF by reducing the risk of falls and improving postural stability.
双盲、随机对照试验。
手术在减轻颈椎病患者的疼痛强度方面是有效的。然而，功能测量表明，结果还不够令人满意。因此，康复计划结合维生素 D 的补充可能会发挥重要作用。
本研究招募了 30 名年龄在 20 至 70 岁之间的患者，他们选择进行前路颈椎椎体间融合术（ACIF）。患者被随机分为安慰剂（Pl）和维生素 D（每天 3200IU D3）补充组。在补充前（BS-第 0 周）、补充后五周（AS-第 5 周）、手术后四周（BSVR-第 9 周）和监督康复后十周（ASVR-第 19 周）进行功能测试，包括平衡极限测试（LOS）、跌倒风险测试（RFT）、姿势稳定性测试（PST）、Romberg 测试和足底压力分布。
血清 25(OH)D3 浓度在五周的补充后显著增加，而 Pl 组则保持不变。维生素 D 补充五周后，RFT 显著降低。此外，在康复后进一步显著下降。在 Pl 组，RFT 没有变化。在两组中，总体姿势稳定性指数（OSI）、LOS 和 Romberg 测试的结果均显著改善；然而，在康复计划结束时，D3 组对 OSI 的影响更为明显。
我们的数据表明，维生素 D 补充在 ACIF 后四周对康复计划产生了积极影响，通过降低跌倒风险和改善姿势稳定性。
