TDP-43 使 ALS 中的 STING 发挥作用。
TDP-43 Puts the STING in ALS.
机构信息
School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia; Queensland Brain Institute, University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
出版信息
Trends Neurosci. 2021 Feb;44(2):81-82. doi: 10.1016/j.tins.2020.12.001. Epub 2020 Dec 20.
In a recent study, Yu et al. demonstrated that TAR DNA-binding protein of 43 kDa (TDP-43) causes inflammation in amyotrophic lateral sclerosis (ALS) by triggering mitochondrial (mt)DNA release into the cytoplasm, which subsequently activates the cytoplasmic DNA-sensing cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway. These results suggest that inhibition of cGAS/STING could help mitigate inflammation-related neuropathology in ALS.
在最近的一项研究中，于等人表明，TAR DNA 结合蛋白 43 kDa（TDP-43）通过触发线粒体（mt）DNA 释放到细胞质中，从而引发肌萎缩侧索硬化症（ALS）中的炎症，随后激活细胞质 DNA 感应环鸟苷酸-腺苷酸合酶（cGAS）/干扰素基因刺激物（STING）途径。这些结果表明，抑制 cGAS/STING 可能有助于减轻 ALS 中的炎症相关神经病理学。
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