School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia; Queensland Brain Institute, University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
Trends Neurosci. 2021 Feb;44(2):81-82. doi: 10.1016/j.tins.2020.12.001. Epub 2020 Dec 20.
In a recent study, Yu et al. demonstrated that TAR DNA-binding protein of 43 kDa (TDP-43) causes inflammation in amyotrophic lateral sclerosis (ALS) by triggering mitochondrial (mt)DNA release into the cytoplasm, which subsequently activates the cytoplasmic DNA-sensing cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway. These results suggest that inhibition of cGAS/STING could help mitigate inflammation-related neuropathology in ALS.
在最近的一项研究中，于等人表明，TAR DNA 结合蛋白 43 kDa（TDP-43）通过触发线粒体（mt）DNA 释放到细胞质中，从而引发肌萎缩侧索硬化症（ALS）中的炎症，随后激活细胞质 DNA 感应环鸟苷酸-腺苷酸合酶（cGAS）/干扰素基因刺激物（STING）途径。这些结果表明，抑制 cGAS/STING 可能有助于减轻 ALS 中的炎症相关神经病理学。
