Department of Internal Medicine II, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Department of Nuclear Medicine, University Hospital Regensburg, Regensburg, Germany.
J Nucl Cardiol. 2022 Jun;29(3):1191-1204. doi: 10.1007/s12350-020-02457-x. Epub 2020 Dec 22.
We assessed the diagnostic value of FDG PET/CT in a real-world cohort of patients with surgically managed infective endocarditis (IE).
We performed a retrospective analysis of all patients hospitalized in a tertiary IE referral medical center from January 2014 to October 2018 fulfilling the following criteria: ICD-10 code for IE and OPS code for both, heart surgery and FDG PET/CT.
Final analysis included 29 patients, whereof 28 patients had surgically proven IE. FDG PET/CT scan was true-positive in 15 patients (sensitivity (SEN) 56%) and false-negative in 12 patients. Combination of Duke criteria (DC) with FDG PET/CT scan resulted in gain of SEN for all patients with confirmed IE (SEN of DC 79% vs SEN of combination DC and FDG PET/CT 89%), driven by a relevant gain in PVE patients only (SEN of DC 78% vs SEN of combination DC and FDG PET/CT 94%). Interestingly, higher prosthesis age was observed in patients with false-negative scans.
We found a SEN of 56% for FDG PET/CT in a real-world cohort of patients with surgically proven IE which was associated with a 16% gain of IE diagnosis in patients with PVE when combined with DC.
我们评估了 FDG PET/CT 在经手术治疗的感染性心内膜炎（IE）患者的真实队列中的诊断价值。
我们对 2014 年 1 月至 2018 年 10 月在一家三级 IE 转诊医疗中心住院且满足以下标准的所有患者进行了回顾性分析：IE 的 ICD-10 编码和心脏手术和 FDG PET/CT 的 OPS 编码。
最终分析包括 29 例患者，其中 28 例患者经手术证实为 IE。FDG PET/CT 扫描在 15 例患者中呈阳性（敏感性（SEN）为 56%），在 12 例患者中呈假阴性。FDG PET/CT 扫描与 Duke 标准（DC）联合使用可使所有确诊 IE 患者的 SEN 提高（DC 的 SEN 为 79%，DC 和 FDG PET/CT 联合的 SEN 为 89%），这主要是由于 PVE 患者的相关提高（DC 的 SEN 为 78%，DC 和 FDG PET/CT 联合的 SEN 为 94%）。有趣的是，假阴性扫描患者的假体年龄更高。
我们在经手术证实的 IE 患者的真实队列中发现 FDG PET/CT 的 SEN 为 56%，当与 DC 联合使用时，在 PVE 患者中 IE 诊断的提高了 16%。
