脑电图功率谱密度和功能连接分析在新生儿缺氧缺血性脑病中的临床意义。

Clinical significance of electroencephalography power spectrum density and functional connection analysis in neonates with hypoxic-ischemic encephalopathy.

机构信息

Neonatology Department, Children's Hospital of Soochow University, Suzhou, China.

Neonatology Department, Affiliated Changzhou Children's Hospital of Nantong University, Changzhou, China.

出版信息

Int J Dev Neurosci. 2021 Apr;81(2):142-150. doi: 10.1002/jdn.10083. Epub 2021 Feb 4.

DOI:10.1002/jdn.10083

PMID:33354792

Abstract

OBJECTIVE

To investigate the effects of electroencephalography (EEG) power and functional connectivity analysis on cerebral cortex function in neonates with hypoxic-ischemic encephalopathy (HIE), and to identify the neurobiological indicators of neural development in HIE.

METHODS

We recruited 20 mild HIE neonates, 15 moderate HIE neonates, and 30 controls. EEG was performed about 72 hr after birth. The power spectral density (PSD) and imaginary part of coherency (ICOH) were analyzed. Gesell developmental schedule (GDS) was used to evaluate the neural development in the mild and moderate HIE groups at 1 year of age, and the correlation between the quantitative EEG results and the state of neural development was analyzed.

RESULTS

Compared with the controls, FP1, FP2, C3, C4, Fz, Cz, Pz , F3, and P4 of moderate HIE neonates showed that the PSD of theta, alpha and beta bands decreased significantly. In terms of the mean whole-brain PSD, the moderate HIE group showed a significant decrease in all frequency bands. ICOH of the moderate HIE group showed that functional connectivity was significantly less than that in the controls mainly in the delta band, and the functional connectivity of the delta, theta, alpha1, and alpha2 bands was markedly reduced compared with the mild HIE. GDS test at 1 year old showed that two infants in the moderate HIE group had suspected neurological delay in gross motor and language. The developmental quotient(DQ) of gross motor, language, and personal-social ability in the moderate HIE group were significantly lower than in the mild HIE group. And there was a significant positive correlation between PSD in each EEG frequency band and GDS score in the moderate HIE group.

CONCLUSION

PSD and ICOH can be used to evaluate brain function. PSD can detect the delayed neurological development in infants with moderate HIE, and can be a neurobiomarker of brain development in HIE.

摘要

目的

探讨脑电图（EEG）功率和功能连接分析对缺氧缺血性脑病（HIE）新生儿大脑皮质功能的影响，识别 HIE 神经发育的神经生物学指标。

方法

我们招募了 20 例轻度 HIE 新生儿、15 例中度 HIE 新生儿和 30 例对照组。出生后约 72 小时进行 EEG 检查。分析了功率谱密度（PSD）和虚部相干（ICOH）。Gesell 发育时间表（GDS）用于评估轻度和中度 HIE 组 1 岁时的神经发育情况，并分析定量 EEG 结果与神经发育状态的相关性。

结果

与对照组相比，中度 HIE 新生儿的 FP1、FP2、C3、C4、Fz、Cz、Pz、F3 和 P4 表现出θ、α和β频段 PSD 明显降低。就全脑 PSD 平均值而言，中度 HIE 组所有频段均显著降低。中度 HIE 组的 ICOH 显示功能连接明显少于对照组，主要是在δ频段，并且与轻度 HIE 相比，δ、θ、α1 和α2 频段的功能连接明显减少。1 岁时的 GDS 测试显示，中度 HIE 组有 2 例婴儿存在粗大运动和语言方面可疑的神经发育迟缓。中度 HIE 组的粗大运动、语言和个人社会能力的发育商（DQ）明显低于轻度 HIE 组。并且中度 HIE 组中各 EEG 频段的 PSD 与 GDS 评分之间存在显著正相关。