Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
Phytother Res. 2021 Jun;35(6):2879-2889. doi: 10.1002/ptr.6992. Epub 2020 Dec 22.
The newly emerging severe acute respiratory syndrome, coronavirus-2 (SARS-CoV-2) is a dangerous pathogen that causes global health problems. It causes a disease called coronavirus disease 2019 (COVID-19) with high morbidity and mortality rates. In SARS-Cov-2-infected patients, elevated oxidative stress and upsurge of inflammatory cytokines are the main pathophysiological events that contribute to the severity and progression of symptoms and death. The polyphenols are natural compounds abundant in fruits and vegetables that are characterized by their high antioxidant and anti-inflammatory effects. Polyphenols have potential as an intervention for preventing respiratory virus infection. The beneficial effects of polyphenols on COVID-19 might be due to multiple mechanisms. Polyphenols can strengthen the body's anti-inflammatory and antioxidant defenses against viral infection. Targeting virus proteins and/or blocking cellular receptors are other plausible antiviral approaches to prevent the entry of the virus and its replication in the host cells. The results on the antiviral effects of various polyphenols, especially on SARS-CoV-2, are promising. The aim of this review is to clarify the role of polyphenols in strengthening antioxidant defenses and upregulating the immune systems of COVID-19 patients and to prevent replication and spreading of the virus.
新出现的严重急性呼吸系统综合征，冠状病毒 2（SARS-CoV-2）是一种危险的病原体，可导致全球健康问题。它会导致一种称为 2019 年冠状病毒病（COVID-19）的疾病，其发病率和死亡率都很高。在 SARS-CoV-2 感染患者中，氧化应激升高和炎症细胞因子激增是导致症状严重程度和进展以及死亡的主要病理生理事件。多酚是水果和蔬菜中富含的天然化合物，其特点是具有很强的抗氧化和抗炎作用。多酚具有作为预防呼吸道病毒感染的干预措施的潜力。多酚对 COVID-19 的有益作用可能归因于多种机制。多酚可以增强身体针对病毒感染的抗炎和抗氧化防御能力。针对病毒蛋白和/或阻断细胞受体是预防病毒进入及其在宿主细胞中复制的其他可行的抗病毒方法。各种多酚的抗病毒作用的结果，特别是对 SARS-CoV-2 的作用，是有希望的。本综述的目的是阐明多酚在增强 COVID-19 患者的抗氧化防御能力和免疫系统方面的作用，并预防病毒的复制和传播。
