Lydiard R B, Laraia M T, Howell E F, Ballenger J C
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston.
J Clin Psychiatry. 1988 Jan;49(1):17-9.
Pharmacological treatment of social phobia has not been extensively studied. Recent reports suggest that social phobia may be treated with monoamine oxidase inhibitors, tricyclic antidepressants, beta-blockers, or clonidine. The authors describe four patients with social phobia who responded moderately to markedly well when treated with the triazolobenzodiazepine alprazolam. Patients with social phobia and patients with agoraphobia with panic attacks differ in the focus of anxiety, sensitivity to lactate infusion, and the pattern of symptoms during anxiety episodes. However, there is significant overlap in the clinical features of these two patient groups. The preliminary finding that several types of pharmacological agents that are effective in treating agoraphobia with panic attacks may also be effective in treating social phobia suggests that the two disorders may share some common pathophysiology.
社交恐惧症的药物治疗尚未得到广泛研究。最近的报告表明，社交恐惧症可用单胺氧化酶抑制剂、三环类抗抑郁药、β受体阻滞剂或可乐定进行治疗。作者描述了4例社交恐惧症患者，他们在使用三唑苯二氮䓬阿普唑仑治疗后，反应中度至显著良好。社交恐惧症患者和伴有惊恐发作的广场恐惧症患者在焦虑焦点、对乳酸输注的敏感性以及焦虑发作期间的症状模式方面存在差异。然而，这两组患者的临床特征有显著重叠。初步研究发现，几种对伴有惊恐发作的广场恐惧症有效的药物制剂可能对社交恐惧症也有效，这表明这两种疾病可能有一些共同的病理生理机制。
