Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kinkai Rehabilitation Hospital, Yonago, Japan.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2022 Mar;29(2):284-296. doi: 10.1080/13825585.2020.1866156. Epub 2020 Dec 23.
We aimed to determine how prefrontal cortex activation and gait speed during walking is affected by cognitive dysfunction and dual-tasking. Eleven and 14 participants were included in the MOCA-J (Japanese version of the Montreal Cognitive Assessment score) < 26 (age, 76.0 ± 5.7 years; sex, six men and five women) and the MOCA-J ≥ 26 groups (age 73.9 ± 4.3 years; sex, seven men and seven women), respectively. We measured prefrontal cortex oxygenated hemoglobin (oxy-Hb) levels (using Pocket NIRS HM), and gait speed during normal and dual-task walking (a letter fluency task was added). The oxy-Hb levels were significantly lower in the MOCA-J < 26 group than in the MOCA-J ≥ 26 group during dual-task walking. The gait speed was significantly lower during dual-task walking, compared with normal walking, in the MOCA-J < 26group.These results may have been influenced by the compensatory mechanisms in the frontal lobe.
我们旨在确定前额叶皮层的激活和行走时的步速如何受到认知功能障碍和双重任务的影响。11 名和 14 名参与者分别被纳入 MOCA-J（蒙特利尔认知评估量表的日语版）得分<26（年龄，76.0±5.7 岁；性别，6 名男性和 5 名女性）和 MOCA-J≥26 组（年龄 73.9±4.3 岁；性别，7 名男性和 7 名女性）。我们使用 Pocket NIRS HM 测量了前额叶皮层的氧合血红蛋白（oxy-Hb）水平，并测量了正常和双重任务行走时的步速（添加了字母流畅性任务）。在双重任务行走时，MOCA-J<26 组的 oxy-Hb 水平明显低于 MOCA-J≥26 组。与正常行走相比，MOCA-J<26 组在双重任务行走时的步速明显较慢。这些结果可能受到额叶的代偿机制的影响。
