Department of Clinical Immunology and Allergology, University Hospital Hradec Králové and Faculty of Medicine in Hradec Králové, Charles University, Czech Republic.
Department of Dermatology and Venereology, University Hospital Hradec Králové and Faculty of Medicine in Hradec Králové, Charles University, Czech Republic.
Acta Medica (Hradec Kralove). 2020;63(4):164-175. doi: 10.14712/18059694.2020.59.
Atopic dermatitis (AD) is a chronic inflammatory skin disease. The progression from AD to bronchial asthma (AB) and allergic rhinitis (AR) is called atopic march. The aim of this study was to evaluate the difference in the sensitization to molecular components in patients suffering from AD in relation to subgroups of patients with AR and AB.
The complete dermatological and allergological examinations were performed. Specific IgE antibodies against 112 molecular components were measured with the multiplex ImmnoCAP ISAC test.
Altogether 104 atopic dermatitis patients (50 men, 54 women) at the average age 40.1 years were examined. The sensitization to molecular components was confirmed in 93.3% of patients. The sensitization to components of mites, grasses, trees, animals, moulds, and shrimps was significantly more frequent in patients with severe form of AD and the sensitization to components of grasses, trees, and moulds was significantly higher in subgroup of patients with AB. In subgroup of patients suffering from AR the higher occurrence of pollen-derived and pollen-food derived PR-10 proteins, grasses, mites, and animals was observed also.
We have confirmed the significant differences in the sensitization to molecular components in patients suffering from severe form of AD, and in subgroups of patients suffering from AB and AR. These molecular components may play the important role in the consecutive development of different allergy pathologies called atopic march.
特应性皮炎（AD）是一种慢性炎症性皮肤病。从 AD 到支气管哮喘（AB）和变应性鼻炎（AR）的进展称为特应性进行曲。本研究的目的是评估患有 AD 的患者对分子成分的致敏与 AR 和 AB 亚组患者之间的差异。
进行了完整的皮肤科和过敏科检查。使用多重 ImmnoCAP ISAC 测试测量了针对 112 种分子成分的特异性 IgE 抗体。
共检查了 104 名特应性皮炎患者（50 名男性，54 名女性），平均年龄为 40.1 岁。93.3%的患者证实对分子成分过敏。在 AD 严重形式的患者中，对螨、草、树、动物、霉菌和虾成分的过敏明显更频繁，而在 AB 亚组的患者中，对草、树和霉菌成分的过敏明显更高。在患有 AR 的亚组患者中，还观察到花粉衍生和花粉-食物衍生 PR-10 蛋白、草、螨和动物的更高发生率。
我们已经证实，在患有严重 AD 形式的患者以及患有 AB 和 AR 的亚组患者中，对分子成分的致敏存在显著差异。这些分子成分可能在特应性进行曲中连续发生的不同过敏病理变化中发挥重要作用。
