Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
Weill Cornell Medical College, New York, New York.
Pediatr Blood Cancer. 2021 Mar;68(3):e28857. doi: 10.1002/pbc.28857. Epub 2020 Dec 23.
Childhood cancer survivors are at increased risk for treatment-related late effects; data are lacking on how coronavirus disease 2019 (COVID-19) infection impacts this cohort. We assessed COVID-19-related symptoms, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG seroprevalence, and rate of COVID-19-related hospitalization among 321 asymptomatic survivors of childhood cancer or transplantation seen for routine long-term follow-up between May and September 2020 in a New York City tertiary cancer center. While 10.9% (n = 35) reported possible COVID-19-related symptoms, 7.8% (n = 20) of those tested had positive SARS-CoV-2 IgG, and one patient (0.3%) required COVID-19-related hospitalization. This report suggests that childhood cancer survivors appear to be at relatively low risk for COVID-19 complications.
儿童癌症幸存者患治疗相关晚期并发症的风险增加；关于新冠病毒疾病 2019（COVID-19）感染如何影响这一人群的数据尚缺乏。我们评估了在 2020 年 5 月至 9 月期间，在纽约市一家三级癌症中心进行常规长期随访的 321 例无症状儿童癌症或移植幸存者的 COVID-19 相关症状、严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）IgG 血清阳性率和 COVID-19 相关住院率。虽然有 10.9%（n=35）报告了可能与 COVID-19 相关的症状，但在接受检测的人群中，有 7.8%（n=20）的人 SARS-CoV-2 IgG 呈阳性，有 1 名患者（0.3%）需要 COVID-19 相关住院治疗。本报告表明，儿童癌症幸存者患 COVID-19 并发症的风险似乎相对较低。
