Berga S L, Mortola J F, Yen S S
Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093.
J Clin Endocrinol Metab. 1988 Jan;66(1):242-4. doi: 10.1210/jcem-66-1-242.
Plasma melatonin levels were determined by a sensitive RIA at 30 min intervals for 24h in 7 women with functional hypothalamic amenorrhea (HA) and in 7 age and season matched normal cycling women in the early follicular phase (NC). While daytime melatonin concentrations were nondetectable in both groups, the integrated nocturnal levels were 3-fold greater in HA (244 +/- 58 (SE) vs 74 +/- 32 pmol-min/Lx10(3), p less than 0.005). This melatonin increase in HA was due to an elevated peak amplitude (p less than 0.01) and extended duration (p less than 0.05). The latter was mostly due to a significant delay in the offset time of the amplified nocturnal melatonin secretion.
采用灵敏的放射免疫分析法（RIA），对7名功能性下丘脑性闭经（HA）女性和7名年龄及季节匹配的处于卵泡早期的正常月经周期女性（NC），每隔30分钟测定一次血浆褪黑素水平，共测定24小时。两组白天的褪黑素浓度均检测不到，但HA组夜间褪黑素的综合水平比NC组高3倍（244±58（标准误）对74±32皮摩尔-分钟/升×10³，p<0.005）。HA组褪黑素水平升高是由于峰值幅度升高（p<0.01）和持续时间延长（p<0.05）。持续时间延长主要是由于夜间褪黑素分泌增强后的偏移时间显著延迟。
