Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Alimentary Tract Research Center, Imam Khomeini Hospital Clinical Research Development Unit, Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Arch Iran Med. 2020 Dec 1;23(12):821-826. doi: 10.34172/aim.2020.109.
Irritable bowel syndrome (IBS) is a functional disease with no exact laboratory or imaging findings. IBS is more common in areas with a history of psychological trauma and war. This study aims to report the prevalence and possible determinants of IBS in southwestern Iran, an area with a notable history of war.
We randomly enrolled 1849 permanent residents in 29 cities aged 20 to 65 years. A validated for Farsi version Rome III criteria and a questionnaire, including demographic data and health history, were administered to each subject. Participants who fulfilled the Rome III criteria were categorized into three groups: Diarrhea dominant (IBS-D), Constipation dominant (IBS-C), and Mixed type (IBS-M).
The total prevalence of IBS was 3.2%, with 70% of subjects being of Arab descent (=0.004). IBS was more common in females, singles, illiterate subjects, and people younger than 30 years; however, none of these differences were statistically significant. People with depression, anxiety, self-report of psychological disorders, and very low socioeconomic status had a significantly higher prevalence of IBS (<0.05). After multivariable logistic regression analysis, very low socioeconomic status had an independent role in IBS predictivity (OR: 2.28, 95% CI: 1.01-5.15).
This study shows a higher prevalence of IBS symptoms in a population-based study in the region compared to counterparts in other regions of Iran. Considering the higher prevalence of self-reported psychological disorders, further studies are recommended to focus on the exact diagnosis of mental disorders and their influence on IBS.
肠易激综合征（IBS）是一种功能性疾病，没有确切的实验室或影像学发现。IBS 在有心理创伤和战争历史的地区更为常见。本研究旨在报告伊朗西南部（一个有显著战争历史的地区）IBS 的患病率和可能的决定因素。
我们随机招募了 1849 名年龄在 20 至 65 岁之间的 29 个城市的常住居民。每个受试者都接受了一份经过验证的 Farsi 版罗马 III 标准和一份问卷，包括人口统计学数据和健康史。符合罗马 III 标准的参与者被分为三组：腹泻型（IBS-D）、便秘型（IBS-C）和混合型（IBS-M）。
IBS 的总患病率为 3.2%，其中 70%的受试者为阿拉伯裔（=0.004）。IBS 在女性、单身、文盲和 30 岁以下人群中更为常见；然而，这些差异均无统计学意义。患有抑郁症、焦虑症、自我报告的心理障碍和极低社会经济地位的人患 IBS 的比例明显更高（<0.05）。经过多变量逻辑回归分析，极低的社会经济地位与 IBS 的预测性独立相关（OR：2.28，95%CI：1.01-5.15）。
与伊朗其他地区的对照相比，本研究显示该地区基于人群的研究中 IBS 症状的患病率更高。鉴于自我报告的心理障碍患病率较高，建议进一步研究关注精神障碍的准确诊断及其对 IBS 的影响。
