Controversial Role of Lecithin:Cholesterol Acyltransferase in the Development of Atherosclerosis: New Insights From an LCAT Activator.
作者信息
Vitali Cecilia, Cuchel Marina
机构信息
Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
出版信息
Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):377-379. doi: 10.1161/ATVBAHA.120.315496. Epub 2020 Dec 23.
Abstract
摘要
相似文献
1
Controversial Role of Lecithin:Cholesterol Acyltransferase in the Development of Atherosclerosis: New Insights From an LCAT Activator.卵磷脂胆固醇酰基转移酶在动脉粥样硬化发展中的争议性作用：来自一种LCAT激活剂的新见解
Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):377-379. doi: 10.1161/ATVBAHA.120.315496. Epub 2020 Dec 23.
2
Is Low-Density Lipoprotein Cholesterol the Key to Interpret the Role of Lecithin:Cholesterol Acyltransferase in Atherosclerosis?低密度脂蛋白胆固醇是解读卵磷脂胆固醇酰基转移酶在动脉粥样硬化中作用的关键吗？
Circulation. 2018 Sep 4;138(10):1008-1011. doi: 10.1161/CIRCULATIONAHA.118.035358.
3
Two Cases of Acquired High-Density Lipoprotein Deficiency with Immunoglobulin G4-Related Lecithin-Cholesterol Acyltransferase Autoantibody.两例获得性高密度脂蛋白缺乏症伴免疫球蛋白 G4 相关卵磷脂胆固醇酰基转移酶自身抗体。
J Atheroscler Thromb. 2023 Aug 1;30(8):1070-1082. doi: 10.5551/jat.63616. Epub 2022 Nov 16.
4
Novel LCAT (Lecithin:Cholesterol Acyltransferase) Activator DS-8190a Prevents the Progression of Plaque Accumulation in Atherosclerosis Models.新型 LCAT（卵磷脂胆固醇酰基转移酶）激活剂 DS-8190a 可阻止动脉粥样硬化模型中斑块堆积的进展。
Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):360-376. doi: 10.1161/ATVBAHA.120.314516. Epub 2020 Oct 22.
5
A review on lecithin:cholesterol acyltransferase deficiency.卵磷脂胆固醇酰基转移酶缺乏症综述。
Clin Biochem. 2015 May;48(7-8):472-5. doi: 10.1016/j.clinbiochem.2014.08.014. Epub 2014 Aug 27.
6
Lecithin:cholesterol acyltransferase, high-density lipoproteins, and atheroprotection in humans.卵磷脂：胆固醇酰基转移酶、高密度脂蛋白与人类的动脉粥样硬化保护
Trends Cardiovasc Med. 2010 Feb;20(2):50-3. doi: 10.1016/j.tcm.2010.03.007.
7
Lecithin:cholesterol acyltransferase: old friend or foe in atherosclerosis?卵磷脂胆固醇酰基转移酶：动脉粥样硬化的老友还是新敌？
J Lipid Res. 2012 Sep;53(9):1783-99. doi: 10.1194/jlr.R024513. Epub 2012 May 7.
8
Lecithin cholesterol acyltransferase: an anti- or pro-atherogenic factor?卵磷脂胆固醇酰基转移酶：抗动脉粥样硬化因子还是促动脉粥样硬化因子？
Curr Atheroscler Rep. 2011 Jun;13(3):249-56. doi: 10.1007/s11883-011-0171-6.
9
Adenoviral expression of human lecithin-cholesterol acyltransferase in nonhuman primates leads to an antiatherogenic lipoprotein phenotype by increasing high-density lipoprotein and lowering low-density lipoprotein.在非人类灵长类动物中，腺病毒介导的人卵磷脂胆固醇酰基转移酶表达通过增加高密度脂蛋白和降低低密度脂蛋白，导致抗动脉粥样硬化脂蛋白表型。
Metabolism. 2009 Apr;58(4):568-75. doi: 10.1016/j.metabol.2008.11.019.
10
Complete and Partial Lecithin:Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis.完整和部分卵磷脂胆固醇酰基转移酶缺乏症与动脉粥样硬化的相关性存在差异。
Circulation. 2018 Sep 4;138(10):1000-1007. doi: 10.1161/CIRCULATIONAHA.118.034706.
引用本文的文献
1
The Role of Punicalagin and Its Metabolites in Atherosclerosis and Risk Factors Associated with the Disease.鞣花酸及其代谢产物在动脉粥样硬化及与疾病相关的危险因素中的作用。
Int J Mol Sci. 2023 May 9;24(10):8476. doi: 10.3390/ijms24108476.
2
Vascular lipidomics analysis reveales increased levels of phosphocholine and lysophosphocholine in atherosclerotic mice.血管脂质组学分析显示，动脉粥样硬化小鼠体内的磷酸胆碱和溶血磷酸胆碱水平升高。
Nutr Metab (Lond). 2023 Jan 4;20(1):1. doi: 10.1186/s12986-022-00723-y.
3
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics.胆固醇稳态在健康和疾病中的调节：从机制到靶向治疗。
Signal Transduct Target Ther. 2022 Aug 2;7(1):265. doi: 10.1038/s41392-022-01125-5.
4
Apolipoprotein A1-Related Proteins and Reverse Cholesterol Transport in Antiatherosclerosis Therapy: Recent Progress and Future Perspectives.载脂蛋白A1相关蛋白与抗动脉粥样硬化治疗中的逆向胆固醇转运：最新进展与未来展望
Cardiovasc Ther. 2022 Jan 10;2022:4610834. doi: 10.1155/2022/4610834. eCollection 2022.
本文引用的文献
1
Recombinant human lecithin-cholesterol acyltransferase in patients with atherosclerosis: phase 2a primary results and phase 2b design.载脂蛋白 A-I Milano 治疗动脉粥样硬化的 2 期临床试验：2a 期初步结果和 2b 期设计
Eur Heart J Cardiovasc Pharmacother. 2022 May 5;8(3):243-252. doi: 10.1093/ehjcvp/pvab001.
2
Novel LCAT (Lecithin:Cholesterol Acyltransferase) Activator DS-8190a Prevents the Progression of Plaque Accumulation in Atherosclerosis Models.新型 LCAT（卵磷脂胆固醇酰基转移酶）激活剂 DS-8190a 可阻止动脉粥样硬化模型中斑块堆积的进展。
Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):360-376. doi: 10.1161/ATVBAHA.120.314516. Epub 2020 Oct 22.
3
Activation of Naturally Occurring Lecithin:Cholesterol Acyltransferase Mutants by a Novel Activator Compound.新型激活化合物激活天然存在的卵磷脂胆固醇酰基转移酶突变体。
J Pharmacol Exp Ther. 2020 Dec;375(3):463-468. doi: 10.1124/jpet.120.000159. Epub 2020 Sep 26.
4
Novel lecithin: cholesterol acyltransferase-based therapeutic approaches.新型卵磷脂：胆固醇酰基转移酶为基础的治疗方法。
Curr Opin Lipidol. 2020 Apr;31(2):71-79. doi: 10.1097/MOL.0000000000000673.
5
HDL and Reverse Cholesterol Transport.高密度脂蛋白和胆固醇逆向转运。
Circ Res. 2019 May 10;124(10):1505-1518. doi: 10.1161/CIRCRESAHA.119.312617.
6
Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol.增加高密度脂蛋白胆固醇的化合物激活卵磷脂胆固醇酰基转移酶的分子基础。
Elife. 2018 Nov 27;7:e41604. doi: 10.7554/eLife.41604.
7
Is Low-Density Lipoprotein Cholesterol the Key to Interpret the Role of Lecithin:Cholesterol Acyltransferase in Atherosclerosis?低密度脂蛋白胆固醇是解读卵磷脂胆固醇酰基转移酶在动脉粥样硬化中作用的关键吗？
Circulation. 2018 Sep 4;138(10):1008-1011. doi: 10.1161/CIRCULATIONAHA.118.035358.
8
Complete and Partial Lecithin:Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis.完整和部分卵磷脂胆固醇酰基转移酶缺乏症与动脉粥样硬化的相关性存在差异。
Circulation. 2018 Sep 4;138(10):1000-1007. doi: 10.1161/CIRCULATIONAHA.118.034706.
9
HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology.高密度脂蛋白与动脉粥样硬化性心血管疾病：复杂生物学的遗传见解。
Nat Rev Cardiol. 2018 Jan;15(1):9-19. doi: 10.1038/nrcardio.2017.115. Epub 2017 Aug 10.
10
Lecithin:Cholesterol Acyltransferase Activation by Sulfhydryl-Reactive Small Molecules: Role of Cysteine-31.卵磷脂：巯基反应性小分子激活胆固醇酰基转移酶：半胱氨酸-31的作用
J Pharmacol Exp Ther. 2017 Aug;362(2):306-318. doi: 10.1124/jpet.117.240457. Epub 2017 Jun 2.
Zotero 插件